成纤维细胞及肌成纤维细胞转化在盆底器官脱垂中的研究进展  

Research Progress of Fibroblast to Myofibroblast Transformation in Pelvic Organ Prolapse

作　　者：赵芷晗 黄国涛[1] 何勇[1] 左晓虎 韩武岳 宁敏琦 汤剑明[1] 洪莉[1] ZHAO Zhihan;HUANG Guotao;HE Yong;ZUO Xiaohu;HAN Wuyue;NING Minqi;TANG Jianming;HONG Li(Department of Gynecology and Obstetrics,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院妇产科,武汉430060

出　　处：《医学综述》2023年第17期3329-3333,共5页Medical Recapitulate

基　　金：国家自然科学基金(81971364,82001527);国家重点研发计划项目(2018YFC2002204);湖北省重点研发计划项目(2022BCA045)。

摘　　要：盆底器官脱垂(POP)是指由于盆底支撑组织减弱导致盆腔器官和邻近阴道壁下降的一组疾病,其发生的病理生理学仍待探究。POP患者阴道壁细胞外基质刚度增加,促使成纤维细胞向肌成纤维细胞转化,进而导致阴道壁机械性能和生物功能发生改变,如胶原代谢受损,最终影响盆底组织的力学性能。此外,POP手术治疗中植入材料的力学性能也可能通过改变成纤维细胞的生物功能影响POP的结局。因此,了解成纤维细胞向肌成纤维细胞转化在POP中的作用具有重要的临床价值。Pelvic organ prolapse(POP)refers to a group of diseases in which the pelvic organ and adjacent vaginal wall fall due to the weakening of pelvic floor supporting tissue.The pathophysiology of POP remains to be explored.In women with POP,the stiffness of the extracellular matrix of the vaginal wall increases,leading to the conversion of vaginal wall fibroblasts to myofibroblasts,which in turn alters mechanical and biological properties,such as impaired collagen metabolism,and ultimately affects the mechanical properties of the pelvic floor tissue.In addition,the mechanical properties of the material implanted in the surgical treatment of POP may also affect the outcome of POP by influencing the biological function of fibroblasts.Therefore,understanding the role of fibroblast to myofibroblast transformation in POP is of great clinical value.

关 键 词：盆底器官脱垂 成纤维细胞 肌成纤维细胞 细胞外基质 

分 类 号：R711.23[医药卫生—妇产科学]