反复妊娠丢失内分泌相关病因研究进展  

Research Progress in Endocrine-related Etiology of Recurrent Pregnant Loss

作　　者：王文婷[1] 汤秋勤[1] 吕娟[1] 程青[1] WANG Wenting;TANG Qiuqin;LYU Juan;CHENG Qing(Department of Family Planning,Women′s Hospital of Nanjing Medical University/Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院,南京市妇幼保健院计划生育科,南京210004

出　　处：《医学综述》2023年第10期1971-1976,共6页Medical Recapitulate

基　　金：国家自然科学基金(81971405)。

摘　　要：反复妊娠丢失(RPL)是危害育龄女性生殖健康的一大问题。其病因复杂,涉及遗传、解剖、免疫、内分泌及环境等相关因素,且近年来发病率逐渐增高,现已成为临床难以处理的不育症之一,给临床治疗带来极大的挑战。随着内分泌相关学科的深入研究,发现内分泌相关因素是RPL发生最重要的危险因素之一。内分泌相关因素主要包括甲状腺功能异常、多囊卵巢综合征及黄体功能不全等,这些因素导致RPL发生的病因和发病机制极其复杂,至今尚未完全阐明,未来可进行深入研究,以期为RPL的预防和治疗提供新思路。Recurrent pregnant loss(RPL)is a major problem that endangers reproductive health of women of childbearing age.Its etiology is complex,including genetic,anatomical,immune,endocrine,environmental and other related factors,and its incidence rate has been gradually increasing in recent years.It has become one of the infertility difficult to deal with clinically,bringing great challenges to the clinical treatment.With the in-depth study of endocrine-related disciplines,it is found that endocrine factors are one of the most important risk factors for the occurrence of RPL.Endocrine-related factors mainly include thyroid dysfunction,polycystic ovary syndrome and luteal phase defect.The etiology and pathogenesis of RPL caused by these factors are extremely complex and have not been fully clarified.In the future,in-depth research can be carried out to provide new ideas for the prevention and treatment of RPL.

关 键 词：反复妊娠丢失 内分泌异常 甲状腺功能异常 多囊卵巢综合征 黄体功能不全 

分 类 号：R714.21[医药卫生—妇产科学]