早发性卵巢功能不全致病因素研究进展  

Research Progress in Pathogenic Factors of Premature Ovarian Insufficiency

作　　者：张莎莎 岳红云[1] ZHANG Shasha;YUE Hongyun(Reproductive Center,Yan′an University Affiliated Hospital,Yan′an 716000,China)

机构地区：[1]延安大学附属医院生殖中心,陕西延安716000

出　　处：《医学综述》2023年第9期1799-1803,共5页Medical Recapitulate

摘　　要：早发性卵巢功能不全(POI)是指女性40岁前出现的一系列卵巢功能减退综合征,可导致女性生育力下降以及远期心血管系统、代谢等方面健康问题,且病情隐匿,易延误诊断。导致POI发生的因素较复杂,可能涉及遗传因素、医源性因素、免疫因素、环境因素等,已引起国内外生殖领域专家广泛关注。近年来,随着延长生殖寿命基因的发现以及对POI致病因素和发病机制的深入探究,有望为POI患者提供精准的治疗方案、生育计划及长期健康管理,为可逆性卵巢功能恢复研究提供方向,从而降低POI发病率。Premature ovarian insufficiency(POI)is a series of syndromes of ovarian insufficiency before the age of 40,which can lead to decreased female fertility,long-term cardiovascular system,metabolism and other health problems,which is featured with hidden condition and delayed diagnosis.The etiology of POI is complex,which may involve genetic factors,iatrogenic factors,immune factors,environmental factors,etc.,which has drawn extensive attention of reproductive experts at home and abroad.In recent years,with the discovery of genes for prolonging reproductive life and in-depth exploration of pathogenic factors and pathogenesis of POI,it is expected to provide the POI patients with accurate treatment programs,fertility planning and long-term health management,and provide directions for the research on reversible ovarian function recovery,so as to reduce the incidence of POI.

关 键 词：早发性卵巢功能不全 致病因素 分子水平 

分 类 号：R711[医药卫生—妇产科学]