膀胱尿路上皮屏障及分泌作用在间质性膀胱炎/膀胱疼痛综合征中的研究进展  

Research Progress of Bladder Urothelial Barrier and Secretion in Interstitial Cystitis/Painful Bladder Syndrome

作　　者：张俊杰 徐和魏 沈百欣 卫中庆 ZHANG Junjie;XU Hewei;SHEN Baixin;WEI Zhongqing(Department of Urology,the Second Affiliated Hospital of Nanjing Medical University/the Second Clinical Medical School of Nanjing Medical University,Nanjing 210011,China)

机构地区：[1]南京医科大学第二临床医学院,南京医科大学第二附属医院泌尿外科,南京210011

出　　处：《医学综述》2023年第9期1804-1808,共5页Medical Recapitulate

基　　金：国家自然科学基金(82270817);国家重点研发计划课题(2018YFC2002204)。

摘　　要：间质性膀胱炎/膀胱疼痛综合征(IC/BPS)是一种至今病因机制不明的慢性无菌性膀胱炎,主要症状为尿频、尿急和持续膀胱区疼痛。目前对IC/BPS的病理生理学研究形成了多种理论,包括上皮通透性增加、糖胺聚糖层破坏、肥大细胞活化、自身免疫、中枢敏化及神经炎症等。膀胱尿路上皮由数层细胞构成,主要起隔绝尿液毒性物质下渗的机械屏障作用,其还具有分泌炎症细胞因子和神经递质的作用。在IC/BPS病变初期干预降低上皮细胞炎症因子表达、增强其机械屏障功能,或将成为全新的治疗靶点。Interstitial cystitis/bladder pain syndrome(IC/BPS)is a chronic aseptic cystitis of unknown etiology.The main symptoms are frequent urination,urgency and persistent bladder pain.Various theories have been formed on the pathophysiology of IC/BPS,including increased epithelial permeability,disruption of the glycosaminoglycan layer,mast cell activation,autoimmunity,central sensitization,and neuroinflammation.Bladder urothelium is composed of several layers of cells,which mainly functions as a mechanical barrier to isolate the infiltration of urinary toxic substances,and also secretes inflammatory cytokines and neurotransmitters.Intervention in the early stage of IC/BPS to reduce the expression of inflammatory factors in epithelial cells and enhance their mechanical barrier function may become a new therapeutic target.

关 键 词：间质性膀胱炎 膀胱疼痛综合征 膀胱尿路上皮 病理改变 

分 类 号：R694.3[医药卫生—泌尿科学]