组蛋白去甲基化酶JMJD3与疾病相关性研究进展  

Research Progress on the Correlation between Histone Demethylase JMJD3 and Diseases

作　　者：张洪堃 袁源[1] 鲍春荣[1] ZHANG Hongkun;YUAN Yuan;BAO Chunrong(Department of Cardio-thoracic Surgery,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院心胸外科,上海200092

出　　处：《医学综述》2023年第11期2081-2085,共5页Medical Recapitulate

基　　金：国家自然科学基金(82000308)。

摘　　要：表观遗传学的主要研究内容包括组蛋白翻译后修饰、遗传物质的甲基化以及非编码RNA调控。表观遗传学在疾病的诊治中具有重要作用,其中含Jumonji结构域蛋白(JMJD)家族对相关组蛋白的修饰是表观遗传学常见的调控途径,参与生殖细胞生成、性激素及其受体活性调节、神经系统功能发育等。组蛋白经由表观遗传控制的甲基化参与多种生物学过程,虽然不同的JMJD家族成员均可参与组蛋白修饰,但不同催化底物的功能不尽相同。JMJD3主要通过作用于组蛋白H327位点(H3K27)的赖氨酸残基催化H3K27me3/2的甲基化修饰过程,引发细胞中基因继发遗传学改变,参与疾病的发生发展。因此,深入研究JMJD3的结构和生物学功能,可以为免疫性疾病、感染性疾病、机体衰老、胚胎发育相关疾病、肿瘤以及心肌梗死等治疗提供新思路。The main research contents of epigenetics includes post-translational modification of histones,methylation of genetic material and regulation of non-coding RNA.Epigenetics plays an important role in the diagnosis and treatment of diseases.The modification of related histones by Jumonji domain-containing protein(JMJD)family is a common regulatory pathway of epigenetics,which is involved in the generation of germ cells,the regulation of the activity of sex hormones and their receptors,and the functional development of the nervous system.The methylation of histones through epigenetic control can participate in a variety of biological processes.Although different members of the JMJD family can participate in the histone modification,but the functions of different catalytic substrates are different.JMJD3 mainly acts on lysine residues at site 27 of histone H3(H3K27),thus catalyzing the methylation modification of H3K27me3/2,causing secondary genetic changes of genes in cells,and thus participating in the occurrence and development of a variety of diseases.Therefore,in-depth study of the structure and biological function of JMJD3 can provide new ideas for the treatment of immune diseases,infectious diseases,body aging,embryonic development related diseases,tumors,myocardial infarction and other diseases.

关 键 词：组蛋白去甲基化酶 表观遗传 含Jumonji结构域蛋白3 

分 类 号：R341[医药卫生—基础医学]