高原低压缺氧损伤与相关炎症细胞因子的研究进展  

Research Progress in Hypobaric Hypoxia Injury of High Altitude and Related Inflammatory Cytokines

作　　者：杨欣悦 刘江伟[1] 余雪飞 梁凯渤 YANG Xinyue;LIU Jiangwei;YU Xuefei;LIANG Kaibo(Anorectal Diagnosis and Treatment Center,General Hospital of Xinjiang Military Command,Urumqi 830000,China;Department of Health Management,General Hospital of Xinjiang Military Command,Urumqi 830000,China;Medical College of Shihezi University,Shihezi 832000,China)

机构地区：[1]新疆军区总医院肛肠诊疗中心,乌鲁木齐830000 [2]新疆军区总医院健康管理科,乌鲁木齐830000 [3]石河子大学医学院,新疆石河子832000

出　　处：《医学综述》2022年第17期3342-3346,共5页Medical Recapitulate

基　　金：新疆维吾尔自治区重点实验室开放课题(2019D04022)。

摘　　要：高原地区具有氧浓度低、气压低、寒冷及紫外线辐射强等特点,这种气候特点会导致处于高原环境的机体出现组织代谢紊乱以及肺水肿、脑水肿等器官功能障碍,甚至死亡。近年,随着高原人群的不断增加,关于高原低压缺氧环境所致器官损伤及相关机制的研究也迫在眉睫。缺氧可刺激机体产生多种炎症细胞因子,促进炎症反应的发生,而炎症反应在高原器官损伤的发生发展中起重要作用。因此,未来深入研究炎症细胞因子与高原低压缺氧损伤的关系及具体机制,可以为疾病的防治提供新思路。The high altitude environment is characterized by low oxygen concentration,low air pressure,cold and strong ultraviolet radiation.These climatic characteristics will lead to a series of tissue metabolic disorders,organ dysfunction such as pulmonary edema and brain edema,and even death.In recent years,due to the increasing number of people stationed at high altitude,it is urgent to further study the organ damage caused by low-pressure and hypoxia environment at high altitude and its related mechanisms.Hypoxia can stimulate the body to produce a series of inflammatory cytokines and promote the occurrence of inflammatory response,which plays an important role in the occurrence and development of organ damage at high altitude.Therefore,in-depth research of the relationship between inflammatory cytokines and hypobaric hypoxia injury in the plateau and the specific mechanism can provide new ideas for the prevention and treatment of related diseases.

关 键 词：高原 低压缺氧 炎症细胞因子 器官损伤 

分 类 号：R825[医药卫生—临床医学]