ω-3多不饱和脂肪酸在妊娠期高血压患者中的临床应用  

Clinical Application ofω-3 Polyunsaturated Fatty Acids in Patients with Gestational Hypertension

作　　者：马春星 刘云春[1] 王思思[1] 石克威 贺英[1] 陈丽华[1] MA Chunxing;LIU Yunchun;WANG Sisi;SHI Kewei;HE Ying;CHEN Lihua(Department of Gynecology,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院妇产科,河北张家口075000

出　　处：《医学综述》2022年第19期3924-3928,共5页Medical Recapitulate

基　　金：张家口市科技计划自筹经费项目(1921027D)。

摘　　要：目的分析ω-3多不饱和脂肪酸在妊娠期高血压患者中的临床应用效果。方法选取2018年6月至2021年6月河北北方学院附属第一医院收治的130例妊娠期高血压患者(包括子痫前期患者)作为研究对象,排除终止妊娠者,最终纳入127例,根据不同治疗方法分为对照组(63例)和研究组(64例)。两组均给予保证睡眠、解痉、降压等基础治疗,对照组同时给予钠钾镁钙葡萄糖注射液静脉滴注(每次100 ml,每日1次),研究组同时给予ω-3多不饱和脂肪酸制剂静脉滴注(每次100 ml,每日1次),两组均连续治疗2周。比较两组治疗前后血压变化情况,白细胞介素(IL)-6、IL-10、肿瘤坏死因子-α(TNF-α)表达水平,以及CD3^(+)、CD4^(+)、CD8^(+)表达水平。结果治疗前后收缩压、舒张压以及IL-6、IL-10、TNF-α、CD3^(+)、CD4^(+)、CD8^(+)表达水平的主效应差异有统计学意义(P<0.05);不考虑测量时间,两组间收缩压、舒张压以及IL-6、IL-10、TNF-α、CD3^(+)、CD8^(+)表达水平的主效应差异有统计学意义(P<0.05);收缩压、舒张压以及IL-6、IL-10、TNF-α、CD3^(+)、CD8^(+)表达水平的组间与时点间存在交互作用(P<0.05),且研究组变化更明显。结论ω-3多不饱和脂肪酸可通过调节机体免疫功能明显降低妊娠期高血压患者炎症反应程度,进而降低血压,改善妊娠期高血压的严重程度。Objective To analyze the clinical effect ofω-3 polyunsaturated fatty acids in patients with gestational hypertension.Methods A total of 130 patients with gestational hypertension(including preeclampsia)admitted to the First Affiliated Hospital of Hebei North University from Jun.2018 to Jun.2021 were selected as the study subjects.Excluding those with pregnancy termination,127 patients were eventually included and divided into a control group(63 cases)and a study group(64 cases)according to different treatment methods.Both groups were given basic treatment such as sleep assurance,spasmolysis and antihypertensive therapy.The control group was given intravenous infusion of sodium,potassium,magnesium,calcium and glucose injection(100 ml each time,once a day),and the study group was given intravenous infusion ofω-3 polyunsaturated fatty acid preparation(100 ml each time,once a day).Both groups were given continuous treatment for 2 weeks.Blood pressure changes,interleukin(IL)-6,IL-10,tumor necrosis factor-α(TNF-α)expression levels,and CD3^(+),CD4^(+),CD8^(+)expression levels before and after treatment were compared between the two groups.Results There were significant differences in the main effects of systolic blood pressure,diastolic blood pressure,IL-6,IL-10,TNF-α,CD3^(+),CD4^(+)and CD8^(+)expression before and after treatment(P<0.05).Regardless of measurement time,there were statistically significant differences in the main effects of systolic blood pressure,diastolic blood pressure,IL-6,IL-10,TNF-α,CD3^(+)and CD8^(+)expression between the two groups(P<0.05).Systolic blood pressure,diastolic blood pressure,IL-6,IL-10,TNF-α,CD3^(+),CD8^(+)expression levels had interactions between groups and time points(P<0.05),and the changes were more obvious in the study group.Conclusionω-3 polyunsaturated fatty acids can significantly reduce the degree of inflammatory response in patients with gestational hypertension by regulating the immune function,thus reducing blood pressure and ameliorating the severity of gestatio

关 键 词：妊娠期高血压 Ω-3多不饱和脂肪酸 免疫营养 免疫调节 炎症介质 

分 类 号：R714.246[医药卫生—妇产科学]