黏蛋白5B在肺部疾病中的研究进展  

Research Progress of Mucin 5B in Lung Diseases

作　　者：李思雨 丁格 彭伊梦 马青 王胜昱[1] LI Siyu;DING Ge;PENG Yimeng;MA Qing;WANG Shengyu(Department of Pulmonary and Critical Medicine,the First Affiliated Hospital of Xi′an Medical University,Xi′an 710077,China)

机构地区：[1]西安医学院第一附属医院呼吸与危重症医学科,西安710077

出　　处：《医学综述》2022年第20期4054-4058,共5页Medical Recapitulate

基　　金：西安市第七批科技计划项目(20YXYJ0001(7))。

摘　　要：气道黏液层对气道产生保护性作用,但其过度分泌会使机体产生疾病。目前气道黏液高分泌的产生机制尚不明确,黏液蛋白是一种黏液层的关键成分,其中黏蛋白5B的表达与多种肺部疾病的发生及发展有密切联系。黏蛋白5B的表达会对黏液纤毛清除产生明显影响,它的缺失会造成气道中黏液的积聚,最终导致由多种细菌引起的慢性感染。因此,黏蛋白5B有望成为气道黏液高分泌治疗的一个靶点,对其研究会为肺部疾病的发生、发展及治疗提供新的理论依据。The airway mucus layer has a protective effect on the airway,but its excessive secretion can cause diseases.At present,the mechanism of the high secretion of airway mucus is not clear.Mucin is a key component of the mucus layer,and the expression of mucin 5B is closely related to the occurrence and development of a variety of lung diseases.Mucin 5B expression has significant impact on mucus cilia clearance,and its absence will cause airway mucus accumulation,which will eventually lead to chronic infection caused by a variety of bacteria.Therefore mucin 5B is expected to become a treatment target for high airway mucus secretion,and the research will provide a new theoretical basis for the occurrence,development and treatment of lung diseases.

关 键 词：慢性阻塞性肺疾病 哮喘 支气管扩张 特发性肺纤维化 肺癌 肺囊性纤维化 黏蛋白5B 

分 类 号：R563[医药卫生—呼吸系统]