MEBT/MEBO治疗慢性难愈合创面疗效和安全性的Meta分析  

Efficacy and safety of MEBT/MEBO in the treatment of chronic refractory wounds:a Meta-analysis

作　　者：杨雅量 葛星月 李文武 竺仕林 姚明哲 唐乾利[1] YANG Yaliang;GE Xingyue;LI Wenwu;ZHU Shilin;YAO Mingzhe;TANG Qianli(School of Graduate,Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院研究生院,广西百色533000

出　　处：《现代医学》2023年第9期1183-1189,共7页Modern Medical Journal

基　　金：国家自然科学基金资助项目(81774327);广西医学高层次骨干人才“139”计划项目(桂卫科教发〔2018〕22号);广西研究生教育创新计划项目(YCSW2023496);右江民族医学院研究生创新计划项目(YXCXJH2022004)。

摘　　要：目的:评价皮肤再生医疗技术治疗慢性难愈合创面的疗效和安全性。方法:计算机检索中国生物医学文献数据库(CBM)、万方数据库(Wanfang database)、中国知网(CNKI)、Cochrane library、PubMed数据库中应用湿润暴露疗法(moist exposed burn therapy,MEBT)/湿润烧伤膏(moisture burn ointment,MEBO)治疗慢性难愈合创面的随机对照研究,检索时限为2012年至2022年,筛选文献、提取资料,使用Cochrane评分手册评价纳入文献的质量,并采用RevMan 5.3软件进行Meta分析。结果:共纳入14篇随机对照研究,包括1228例患者,试验组应用MEBT/MEBO加常规治疗,对照组进行常规治疗。Meta分析结果显示,试验组创面愈合率更高(RR=1.84,95%CI 1.50~2.26,P<0.001),试验组治疗有效率更高(RR=4.81,95%CI 3.18~7.27,P<0.001),试验组创面平均愈合时间更短(SMD=-1.39,95%CI-1.60~-1.17,P<0.001),试验组创面肉芽组织出现时间更早(SMD=-1.85,95%CI-2.15~-1.55,P<0.001),所有纳入研究均无不良反应及并发症病例报道。结论:MEBT/MEBO治疗慢性难愈合创面有良好疗效,且安全性高,但受纳入文献质量和数量的限制,结论仍需更多高质量随机对照研究进一步验证。Objective:To evaluate the efficacy and safety of skin regeneration medical technology in treating chronic refractory wounds.Methods:CBM,Wanfang Database,CNKI,Cochrane Library,and PubMed database were searched by computer for randomized controlled trials of moist exposed burn therapy(MEBT)/moisture burn ointment(MEBO)in treating chronic refractory wounds.The search years were from January 2012 to April 2022.The literature was screened,the data was extracted,the Cochrane Scoring Manual assessed the quality of included literature,and the RevMan 5.3 software was used for Meta-analysis.Results:A total of 14 random control tests(RCTs)involving 1228 patients were included.The experimental group was treated with MEBT/MEBO combined with conventional treatment,while the control group was treated with conventional treatment.Meta-analysis results showed that the wound healing rate of the experimental group was higher than that of the control group(RR=1.84,95%CI 1.50~2.26,P<0.001),and the effective rate of the experimental group was higher than that of the control group(RR=4.81,95%CI 3.18~7.27,P<0.001).The mean wound healing time in the experimental group was shorter than that in the control group(SMD=-1.39,95%CI-1.60~-1.17,P<0.001),and the time of granulation tissue appeared in the experimental group was earlier than that in the control group(SMD=-1.85,95%CI-2.15~-1.55,P<0.001).None of the studies reported adverse reactions and complications.Conclusion:MEBT/MEBO have good efficacy and high safety in treating chronic refractory wounds.However,due to the limitation of the quality and quantity of the included literature,the conclusion still needs to be further verified by more high-quality RCTs.

关 键 词：皮肤再生医疗技术 湿润暴露疗法 湿润烧伤膏 慢性创面 META分析 

分 类 号：R641[医药卫生—外科学]