血清鸢尾素与肌肉减少症的相关研究进展  

Research progress of the relationship of irisin with sarcopenia

作　　者：卢雨钒 杨雪锋[1] Lu Yufan;Yang Xuefeng(Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science and Technology,Wuhan 430030 Hubei China)

机构地区：[1]华中科技大学同济医学院公共卫生学院营养与食品卫生学系,湖北武汉430030

出　　处：《肿瘤代谢与营养电子杂志》2023年第5期585-589,共5页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家自然科学基金(82173511)。

摘　　要：肌肉减少症是一种与年龄相关的肌肉质量、力量以及功能进行性下降的疾病,严重降低了患者的生活质量,加重了社会经济负担。随着全球人口老龄化进程的加速,肌肉减少症已成为危害我国乃至全球老年人群健康的重大公共卫生问题之一,但缺乏有效的防治措施。鸢尾素作为一种由骨骼肌分泌的活性蛋白因子,通过丝裂原活化蛋白激酶等细胞信号通路调节肌肉、骨骼代谢以及糖脂代谢,影响成肌分化和肌母细胞融合等生物学过程,促进骨骼肌细胞生长和增殖,维持肌肉质量及功能。鸢尾素缺乏可导致骨骼肌质量下降和肌力减退,与肌肉减少症的发生和发展密切相关。血鸢尾素水平有可能成为肌肉减少症等代谢性相关疾病的治疗靶点和早期监测生物标志物。然而,目前鸢尾素与肌肉减少症发生风险的关联研究的证据有限,缺乏深入分析,相关机制尚未阐明。本文就鸢尾素与肌肉减少症的相关研究进展进行综述,旨在为老年肌肉减少症的早期筛查、诊断以及干预治疗提供新的思路。Sarcopenia is an age-related progressive disease associated with decline in muscle mass strength and function which severely reduces the quality of life of sufferers and increases the social and economic burden.With the acceleration of the process of global population aging sarcopenia has become one of the major public health problems that impair the health of the elderly people in our country and even the in the world but there are lack of effective prevention and control measures.Irisin as an active protein factor secreted by skeletal muscle regulates muscle and bone metabolism as well as glucose and lipid metabolism through mitogen-activated protein kinase and other cell signaling pathways affects biological processes such as myoblast differentiation and myoblast fusion promotes the growth and proliferation of skeletal muscle cells and maintains muscle mass and function.Irisin deficiency can lead to the decline of skeletal muscle mass and muscle strength which is closely related to the occurrence and development of sarcopenia.Blood irisin levels have the potential to be a therapeutic target and an early monitoring biomarker for metabolically related diseases such as sarcopenia.However the evidence from current studies on the association between irisin and the risk of sarcopenia is limited and the relevant mechanism has not been clarified.This article reviews the research progress of irisin and sarcopenia aiming to provide new ideas for early screening diagnosis and intervention treatment of senile sarcopenia.

关 键 词：鸢尾素 肌肉减少症 衰老 生物标志物 

分 类 号：R685[医药卫生—骨科学]