陈皮配方颗粒提取工艺的优化  

Optimization of Extraction Process for Tangerine Peel Formula Granules

作　　者：黎桃敏 彭帮贵 张兰兰 何荣荣 刘燎原 LI Taomin;PENG Banggui;ZHANG Lanlan;HE Rongrong;LIU Liaoyuan(Guangdong Provincial Key Lab.of Traditional Chinese Medicine Formula Granule,Guangdong Yi Fang Pharmaceutical Co.,Ltd.,Foshan 528244)

机构地区：[1]广东一方制药有限公司,广东省中药配方颗粒企业重点实验室,广东佛山528244

出　　处：《中国医药工业杂志》2023年第8期1241-1246,共6页Chinese Journal of Pharmaceuticals

基　　金：佛山市新冠肺炎科技攻关项目(2020001000206)。

摘　　要：利用Box-Behnken设计-响应面法,以煎煮时间、加水量、煎煮次数为考察因素,设计三因素三水平试验。通过层次分析法(AHP)、熵权法和AHP结合熵权法分别对评价指标,即出膏率以及芸香柚皮苷、橙皮苷、川陈皮素和橘皮素的含量赋予权重。然后以上述5个指标的综合评分为评价指标,优选陈皮配方颗粒的提取工艺。结果表明,优化提取工艺参数为:加14倍量水、煎煮3次、每次60 min。验证试验表明,该提取工艺稳定、简单、可行,可为陈皮配方颗粒的制剂工艺研究提供参考。A three-factor and three-level experiment was conducted with decoction time,adding amount of water and decocting times as the independent variables by Box-Behnken design combined with response surface methodology.The weights for evaluating indexes,namely the extraction yield and the contents of narirutin,hesperidin,nobiletin and tangeretin were calculated by analytic hierarchy process(AHP),entropy weight method and the combination of AHP and entropy weight method,respectively.Then,the comprehensive score of the above 5 indicators was used as the evaluation index to optimize the extraction process parameters of tangerine peel formula granules.The results showed that the optimized extraction process parameters were as follows:adding 14 times of the amount of water,decocting 3 times,and 60 min per extraction.The results of verification test showed that the extraction process was stable,simple and feasible,which could provide a reference for the preparation process study of tangerine peel formula granules.

关 键 词：陈皮配方颗粒 BOX-BEHNKEN设计 响应面法 层次分析法 熵权法 权重 提取 

分 类 号：R944.27[医药卫生—药剂学]