蜂毒肽的药理学及纳米运载系统研究进展  

Research progress in pharmacology and nano-delivery system of melittin

作　　者：张善芳 李莉 陈瑜 申燕华 苑兴华 ZHANG Shanfang;LI Li;CHEN Yu;SHEN Yanhua;YUAN Xinghua(Department of Respiratory Critical Care,Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 201999,China;Clinical Research Institute of Integrated Traditional Chinese and Western Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海市宝山区中西医结合医院呼吸危重症医学科,上海201999 [2]上海中医药大学附属岳阳中西医结合医院中西医结合临床研究所,上海200437

出　　处：《上海中医药大学学报》2023年第5期83-93,共11页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81903977);上海市自然科学基金资助项目(21ZR1447700);上海市卫健委科研项目(202140234)。

摘　　要：蜂毒肽(MEL)是蜂毒的主要成分,对癌症等疾病的治疗有独特的优势,然而由于MEL具有较强的毒副作用,其药物研发及临床应用一直受到阻碍。近年来药理学研究表明,MEL除具有较强的细胞膜表面活性和溶血活性外,还具有较好的生物活性和药理作用,包括抗菌、抗病毒、抗炎、抗肿瘤、抗纤维化等作用。此外,在MEL的给药系统方面也采取了多种策略,如改进MEL及其共轭物、采用纳米运载工具等。兹就MEL的药理学及纳米运载系统的研究进展进行综述,以期为今后MEL的研究提供参考。Melittin(MEL)is the main component of bee venom and has unique advantages in the treatment of cancers and other diseases.However,due to the strong toxic and side effects of MEL,its drug development and clinical application have been hindered.Recent pharmacological studies have shown that MEL not only has strong cell membrane surface activity and hemolytic activity,but also has good biological activity and pharmacological effects,including antibacterial,antiviral,anti-inflammatory,anti-tumor,anti-fibrosis and so on.In addition,many strategies have also been adopted in the MEL drug delivery systems,such as improving MEL and its conjugates,and using nano-delivery vehicles.This article reviews the research progress of MEL's pharmacology and nano-delivery system in order to provide reference for the future research of MEL.

关 键 词：蜂毒肽 药理学 纳米运载系统 抗肿瘤 抗炎 

分 类 号：R285[医药卫生—中药学]