基于关联规则及复杂网络分析探讨古代中风方剂用药规律  

Rules of Ancient Traditional Chinese Medicine Prescriptions for Stroke Based on Association Rules and Complex Network

作　　者：王少卿[1] 南一楠[2] 朱文浩[3] 周纡[1] 孔令博[4] 樊永平[1] WANG Shaoqing;NAN Yinan;ZHU Wenhao;ZHOU Yu;KONG Lingbo;FAN Yongping(Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;China-Japan Friendship Hospital,Beijing 100029,China;Zibo Hospital of Traditional Chinese Medicine,Zibo 255300,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]首都医科大学附属北京天坛医院,北京100070 [2]中日友好医院,北京100029 [3]淄博市中医医院,淄博255300 [4]北京中医药大学附属东直门医院,北京100700

出　　处：《世界中医药》2023年第18期2675-2679,共5页World Chinese Medicine

基　　金：国家自然科学基金项目(82104578);北京中医药大学2020年度基本科研业务费项目(2020-JYB-ZDGG-110)。

摘　　要：目的:探讨古代中医治疗中风的用药规律。方法:收录古籍中治疗中风的方剂422首,用Epidata建立数据库,对药物的使用频次、类别、使用比例等进行统计分析,并运用关联规则及复杂网络分析对其用药规律进行提取。结果:纳入方剂涉及中药18个种类,药物221种,使用频次共4058次;使用比例较高的依次为解表药、补益药、祛风湿药、清热药、活血药等;使用频次较高的药物依次为防风、川芎、当归、人参、白芍等;药物的使用以温、平、微温、微寒、寒为主,性味以辛、甘、苦为主,归经多以脾、肝、肺、心为主;根据Apriori算法,共产生496条规则,运用复杂网络分析提取了核心药物节点:防风、甘草、当归、川芎、人参和羌活。结论:古代中医治疗中风,重视祛风通络、补气养血治法的运用。Objective:To analyze and discuss the medication rules of ancient traditional Chinese medicine(TCM)prescriptions for stroke.Methods:A total of 422 prescriptions for stroke in ancient TCM books were collected,and a database was established by Epidata.Then the frequency,category,and proportion of the prescriptions were statistically analyzed.Finally,association rules and complex network were employed for exploring the medication rules.Results:In the prescriptions collected,there involved 221 herbal medicines in 18 categories,with the total frequency of usage of 4058.The top 5 categories were exterior-relieving medicine,tonifying and reinforcing medicine,wind-dampness-dispelling medicine,heat-clearing medicine,and blood-activating medicine.The top 5 herbal medicines in the frequency of usage included Radix Saposhnikovia,Rhizoma Chuanxiong,Radix Angelicae Sinensis,Radix et Rhizoma Ginseng,and Radix Paeoniae Alba.The herbal medicines were mainly warm,moderate,mild warm,mild cold,and cold,with pungent,sweet,and bitter flavors.They largely acted on spleen,liver,lung,and heart.According to Apriori algorithm,496 rules were generated,and core medicine nodes were found according to complex network,which were Radix Saposhnikovia,Radix Et Rhizoma Glycyrrhizae,Radix Angelicae Sinensis,Rhizoma Chuanxiong,Radix et Rhizoma Ginseng,and Rhizomaet Radix Notopterygii.Conclusion:The treatment of stroke in ancient TCM focuses on dispelling wind,dredging collaterals,tonifying qi,and nourishing blood.

关 键 词：中风 古代方剂 用药规律 关联规则 复杂网络分析 祛风通络 补气养血 

分 类 号：R242[医药卫生—中医临床基础]