系统性红斑狼疮疾病活动性对外周血免疫球蛋白及淋巴细胞绝对值水平的影响  

The effect of systemic lupus erythematosus disease activity on the absolute levels of peripheral blood immunoglobulins and lymphocytes

作　　者：吴品 邱彩玲 陈祥云 林景涛 宣春 WU Pin;QIU Cailing;CHEN Xiangyun;LIN Jingtao;XUAN Chun(Department of Laboratory Medicine,Dalang Hospital of Dongguan,Guangdong,Dongguan 523770,China;Department of Blood Transfusion,Dalang Hospital of Dongguan,Guangdong,Dongguan 523770,China)

机构地区：[1]广东省东莞市大朗医院检验科,广东东莞523770 [2]广东省东莞市大朗医院输血科,广东东莞523770

出　　处：《中国医药科学》2023年第19期141-143,164,共4页China Medicine And Pharmacy

基　　金：广东省东莞市社会发展科技重点项目(20211800905322)。

摘　　要：目的探讨外周血免疫球蛋白免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)及淋巴细胞绝对值(Lym#)与系统性红斑狼疮(SLE)疾病活动性的相关性。方法回顾性分析2020年1月至2022年8月广东省东莞市大朗医院收治确诊的100例SLE患者病例资料(观察组),根据SLE疾病活动度(SLEDIA)评分分为活动期SLE患者50例(SLEDIA评分≥5分,活动组)、非活动期患者50例(SLEDIA评分≤4分,非活动组),另遵循随机抽样原则按入院先后选取同期健康体检者50名(对照组)。分别检测三组间外周血免疫球蛋白IgA、IgG、IgM及Lym#水平,比较各组指标的相关性。结果与对照组比较,活动期与非活动期SLE患者外周血中的免疫球蛋白IgA和IgG均明显增高,差异有统计学意义(P<0.05),IgM和Lym#明显降低,差异有统计学意义(P<0.05);与非活动组比较,活动期SLE患者血清中的免疫球蛋白IgA和IgG明显增高,差异有统计学意义(P<0.05),活动组与非活动组IgM和Lym#比较,差异无统计学意义(P>0.05)。结论外周血免疫球蛋白IgA、IgG、IgM及Lym#与SLE活动性密切相关,可作为动态监测SLE的观察指标。Objective To explore the correlation between the immunoglobulins immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)and the absolute value of lymphocyte(Lym#)in peripheral blood and the disease activity of systemic lupus erythematosus(SLE).Methods A retrospective analysis was conducted on the data of 100 confirmed SLE patients admitted to Dalang Hospital of Dongguan,Guangdong Province from January 2020 to August 2022(observation group).According to the SLE disease activity index(SLEDIA)score,they were divided into 50 active SLE patients(SLEDIA score≥5 points,active group)and 50 inactive SLE patients(SLEDIA score≤4 points,inactive group).In addition,a random sampling principle was followed to select 50 healthy examinees(control group)in the same period of admission.The levels of IgA,IgG,IgM,and Lym#in peripheral blood between the three groups were tested,and the correlation of each group’s indicators was compared.Results Compared with the control group,the immunoglobulin IgA and IgG in the peripheral blood of active and inactive SLE patients were significantly increased,with a statistically significant difference(P<0.05).IgM and Lym#were significant ly decreased,wit h a st atistically significant difference(P<0.05);Compared with the inactive group,the immunoglobulin IgA and IgG in the serum of active SLE patients were significantly increased,with a statistically significant difference(P<0.05).There was no significant difference in IgM and Lym#between the active and inactive groups(P>0.05).Conclusion Peripheral blood immunoglobulins IgA,IgG,IgM,and Lym#were closely related to the activity of systemic lupus erythematosus,and could be used as observation indicators for dynamic monitoring of systemic lupus erythematosus.

关 键 词：外周血 免疫球蛋白 淋巴细胞绝对值 系统性红斑狼疮 疾病活动性 相关性 

分 类 号：R593.241[医药卫生—内科学]