血浆FIB-PLT-DD联合检测在慢性肺源性心脏病治疗中的临床意义  

Clinical significance of combined detection of plasma FIB-PLTDD in the treatment of pulmonary heart disease

作　　者：吴颖 高蔚 翁婷 WU Ying;GAO Wei;WENG Ting(Department of Respiratory,the Affiliated Suqian Hospital of Xuzhou Medical University,Nanjing Drum Tower Hospital Group Suqian Hospital,Jiangsu,Suqian 223800,China)

机构地区：[1]徐州医科大学附属宿迁医院、南京鼓楼医院集团宿迁医院呼吸科,江苏宿迁223800

出　　处：《中国医药科学》2023年第19期177-180,185,共5页China Medicine And Pharmacy

摘　　要：目的观察慢性肺源性心脏病(CPHD)患者急性加重期和缓解期及慢性阻塞性肺疾病急性加重期(AECOPD)患者血浆纤维蛋白原(FIB)、血小板计数(PLT)、血浆D-二聚体(DD)等指标,评估其在CPHD诊疗中的价值。方法选取2019年3月至2022年4月在南京鼓楼医院集团宿迁医院呼吸科收治的53例CPHD急性加重期患者及AECOPD患者78例,均测定凝血功能、血常规、血浆D-二聚体。CPHD急性加重期患者53例均为采用综合方法进行治疗后症状短期明显缓解者,且缓解后均复测上述指标者,将所测数据分为CPHD治疗后缓解期组,并做正常对照组。结果CPHD急性加重期患者FIB、DD水平均明显高于CPHD治疗后缓解期组、AECOPD组和对照组,差异有统计学意义(P<0.05);部分凝血酶原时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、国标值(INR)水平明显低于CPHD治疗后缓解期组、AECOPD组和对照组,差异有统计学意义(P<0.05);CPHD治疗后缓解期组、AECOPD组FIB、DD、TT均明显高于正常对照组,差异有统计学意义(P<0.05)。CPHD急性加重期患者PLT显著低于正常对照组(P<0.05);而平均血小板体积(MPV)则显著高于正常对照组(P<0.05)。随着病情好转,达到CPHD缓解期时,PLT增高,MPV下降,与正常对照组比较,差异有统计学意义(P<0.05)。AECOPD组的FIB、DD、RBC、HB高于正常对照组,差异有统计学意义(P<0.05)。AECOPD组PLT、MPV与正常对照组比较,差异无统计学意义(P>0.05),但均比正常对照组高。结论FIB、PLT及DD在CPHD患者的诊断、治疗及预后判断中均具有重要价值。Objective To observe the indices of plasma fibrinogen(FIB),platelet count(PLT)and plasma D-dimer(DD)in patients with chronic pulmonary heart disease(CPHD)in acute exacerbation and remission,and in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and to evaluate their significance in the diagnosis and treatment of pulmonary heart disease.Methods A total of 53 patients with acute exacerbation period of chronic pulmonary heart disease and 78 patients with AECOPD admitted to and treated in the Department of Respiratory of Nanjing Drum Tower Hospital Group Suqian Hospital from March 2019 to April 2022 were selected.Coagulation function,blood routine and plasma DD were all detected.All the 53 enrolled patients with acute exacerbation period of pulmonary heart disease were all treated with comprehensive methods and their symptoms significantly alleviated in the short term.For those who have retested the above indices after remission,the measured data were divided into the remission period group after treatment for pulmonary heart disease,and a normal control was conducted.Results The levels of FIB and DD in patients with acute exacerbation period of pulmonary heart disease were all significantly higher than those in the remission period group,AECOPD group and the control group after treatment,with statistically significant differences(P<0.05).The levels of activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT)and international normalized ratio(INR)were significantly lower than those after treatment of the pulmonary heart disease in the remission period group,the AECOPD group and the control group,with statistically significant differences(P<0.05).The FIB,DD and TT levels in patients with pulmonary heart disease in the remission period group and the AECOPD group were all significantly higher than those in the normal control group,with statistically significant differences(P<0.05).The PLT of patients with acute exacerbation of pulmonary heart disease was signifi

关 键 词：慢性肺源性心脏病 慢性阻塞性肺疾病 纤维蛋白原 D-二聚体 血小板 

分 类 号：R563.9[医药卫生—呼吸系统]