诺氟沙星金属配合物的合成及抗菌活性研究  

Synthesis and Antibacterial Activity of Complex with Norfloxacin

作　　者：邹玉龙 郭强[2] 宋伟东 邹桂华[2] 孙雪 沈广志[2] ZOU Yulong;GUO Qiang;SONG Weidong;ZOU Guihua;SUN Xue;SHEN Guangzhi(Department of Pharmacy,Mudanjiang Medical University Aff iliated Hongqi Hospital,Mudanjiang 157011,China;School of Pharmacy,Mudanjiang Medical University,Mudanjiang 157011,China;Mudanjiang Medical University Aff iliated Second Hospital,Mudanjiang 157011,China)

机构地区：[1]牡丹江医学院附属红旗医院药学部,黑龙江牡丹江157011 [2]牡丹江医学院药学院,黑龙江牡丹江157011 [3]牡丹江医学院附属第二医院,黑龙江牡丹江157011

出　　处：《化工管理》2023年第31期150-153,共4页Chemical Engineering Management

基　　金：黑龙江省自然科学基金(LH2021B028)。

摘　　要：采用水热法合成诺氟沙星配合物[Ni(NF)_(2)]_(2)H_(4)[SiW_(12)O_(40)]·8H_(2)O(1),利用元素分析、红外光谱、紫外可见光谱等手段对配合物1进行基础表征。采用纸片药敏测试法和二倍稀释抑菌实验法测试了配合物1和配体对金黄色葡萄球菌、大肠杆菌和枯草杆菌的抑菌活性。利用紫外光谱法研究配合物1与CT-DNA之间的相互作用。结果表明,配合物1对金黄色葡萄球菌、大肠杆菌和枯草杆菌均有不同程度的抑菌活性,配合物1通过嵌插方式与CT-DNA相互作用,结合常数(Kb)为2.0×10^(4)L/mol。配合物1以嵌插方式与CT-DNA相互作用,配合物1对枯草杆菌具有显著的抑菌效果。The complex[Ni(NF)_(2)]_(2)H_(4)[SiW_(12)O_(40)]·8H_(2)O(1)was synthesized by hydrothermal methods.The complex 1 was characterized by the elemental analysis,infrared spectroscopy and ultraviolet spectroscopy.The f ilter paper test method and the double dilution method were used to compare the inhibitory effects of complex 1 and ligands on three bacteria,including Staphylococcus aureus,Escherichia coli and Bacillus subtilis.The interactions between the complex 1 and CT-DNA were evaluated by ultraviolet spectroscopy.The results show that the complex 1 had different degrees of inhibition on Staphylococcus aureus,Escherichia coli and Bacillus subtilis.The results showed that the complex 1 could interact with CT-DNA by an intercalative mode,the combining ratio was 2.0×10^(4)L/mol.The complex 1 could interact with CT-DNA by an intercalative mode.The complex 1 had signif icant antibacterial effects on Bacillus subtilis.

关 键 词：诺氟沙星 配合物 抗菌活性 DNA 

分 类 号：R9[医药卫生—药学]