The tRNA-derived fragment tRF-5022a positively regulates melanogenesis  

作　　者：Si Li Lan Zhang Jing Chen Ling Jiang Chuhan Fu Ao Huang Xinxin Lei Siyu Yang Qinghai Zeng Ke Cao 

机构地区：[1]Department of Dermatology,The Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China [2]Department of Oncology,The Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China [3]Institute of Chinese Materia Medica,Hunan Academy of Chinese Medicine,Changsha,Hunan 410013,China

出　　处：《Genes & Diseases》2023年第4期1203-1205,共3页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82103704);the Natural Science Foundation of Hunan Province(China)(No.2021JJ20089,2022JJ70148);Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South Uni-versity,Hunan,China(No.YX202007);the Hunan Science and Technology Innovation Project(China)(No.2021RC3035).

摘　　要：The tRNA-derived fragments(tRFs)are small non-coding RNAs containing fewer than 50 nucleotides that are abundant in humans and have various biological functions.However,their roles and mechanisms in melanogenesis are unclear.In this study,we firstly investigated the change in the expres-sion profile of tRFs in melanocytes after UVB irradiation through tsRNA sequencing.UVB-induced melanogenesis led to the upregulation of 119 tRFs and the downregulation of 103 tRFs.

关 键 词：functions melan GENESIS 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]