脉冲电磁场治疗骨质疏松症的临床研究进展  

Clinical research progress of pulsed electromagnetic field in the treatment of osteoporosis

作　　者：杨建成 曾玉红[1] YANG Jiancheng;ZENG Yuhong(Department of Osteoporosis,Honghui Hospital,Xi’an Jiaotong University,Xi’an 710054,China)

机构地区：[1]西安交通大学附属西安市红会医院骨质疏松科,陕西西安710054

出　　处：《中国骨质疏松杂志》2023年第10期1503-1507,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(52107238);西安市科技计划项目(22YXYJ0022)。

摘　　要：脉冲电磁场(pulsed electromagnetic field,PEMF)作为一种无创、安全、有效的物理治疗手段,早期在临床上用于治疗骨折延迟愈合和不愈合的患者,目前已用于骨质疏松症的临床辅助治疗。体外及动物模型研究已经证实PEMF能够刺激成骨细胞的骨形成而抑制破骨细胞的骨吸收,最终实现骨结构的完整及骨量和骨强度的维持。大量临床研究也表明PEMF在增加骨质疏松症患者骨密度、缓解疼痛及改善患者生活质量方面具有很好的治疗效果,但是PEMF对骨质疏松症积极作用的确定性仍需进一步研究。本文对国内外有关PEMF治疗骨质疏松症的相关临床文献进行了总结,并对可能机制进行了探讨,旨在为日后的临床研究提供一定的参考。Pulsed electromagnetic field(PEMF),as a non-invasive,safe and effective physical therapy,is first applied in treating patients with delayed healing and non-union of fractures,and is now used as a clinical adjunct in the treatment of osteoporosis.In vitro and animal studies have demonstrated that PEMF stimulates bone formation by osteoblasts and inhibits bone resorption by osteoclasts,ultimately achieving structural integrity of bone and preservation of bone mass and bone strength.A large number of clinical studies have also shown that PEMF has satisfactory therapeutic effect on increasing bone mineral density,relieving pain,and improving life quality of patients with osteoporosis.However,the certainty of the positive effects of PEMF on osteoporosis still needs to be further investigated.In this review,we summarize the relevant clinical literature on PEMF for the treatment of osteoporosis in the domestic and overseas,and discuss the possible mechanisms,aiming to provide some reference for future clinical studies.

关 键 词：脉冲电磁场 骨质疏松 骨密度 疼痛 

分 类 号：R454[医药卫生—治疗学]