HMGB1介导TLR4/NF-κB信号通路干预骨关节炎研究进展  

Research progress in the intervention of osteoarthritis by HMGB1 through TLR4/NF-κB signaling pathway

作　　者：谢兴文 陈欣[1,2] 刘建军 李元贞[1] 席芳琴 齐伟 闫文 陈一新 XIE Xingwen;CHEN Xin;LIU Jianjun;LI Yuanzhen;XI Fangqin;QI Wei;YAN Wen;CHEN Yixin(The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学附属医院,甘肃兰州730000 [2]甘肃中医药大学,甘肃兰州730030

出　　处：《中国骨质疏松杂志》2023年第10期1519-1522,1527,共5页Chinese Journal of Osteoporosis

基　　金：兰州市科技发展指导性项目(2020-ZD-65);甘肃省青年科技基金(20JR10RA345);甘肃省卫生健康行业科研项目(GSWSKY-2021-009);兰州市城关区科技局(2020JSCX0065);甘肃中医药大学附属医院创新基金(gzfy-2020-24);甘肃省拔尖领军人才项目。

摘　　要：骨关节炎(osteoarthritis,OA)作为临床常见老年退行性疾病,目前尚无有效治疗手段。研究发现OA是一种慢性低度炎性疾病。损伤相关分子模式HMGB1(high mobility group box-1)在OA病理过程中发挥中心分子作用。HMGB1与固有免疫模式识别受体TLR4(toll-like receptor 4,TLR4)结合后激活NF-κB信号通路导致OA软骨退变和滑膜炎等免疫炎症反应。通过综述HMGB1介导TLR4/NF-κB信号通路在OA发病机制中的作用,为靶向阻断HMGB1治疗OA提供理论依据和参考。Osteoarthritis(OA)is a common clinical degenerative disease,but there is no effective treatment at present.Studies have found that OA is a chronic low-grade inflammatory disease.Damage-related molecular pattern HMGB1(high mobility group box-1)plays a central molecular role in the pathological process of OA.HMGB1 binds to Toll-like receptor(4TLR4),the innate immune pattern recognition receptor,and activates NF-κB signaling pathway,leading to OA cartilage degeneration and synovitis.This article reviews the role of HMGB1 mediated TLR4/NF-κB signaling pathway in the pathogenesis of OA,so as to provide theoretical basis and reference for the targeted blockade of HMGB1 in the treatment of OA.

关 键 词：骨关节炎 HMGB1/TLR4/NF-κB信号通路 研究进展 

分 类 号：R684[医药卫生—骨科学]