miR-146a介导TLR4/NF-κB信号通路延缓骨关节炎的作用及机制  

The effect and mechanism of miR-146a mediating TLR4/NF-κB signaling pathway in osteoarthritis

作　　者：刘建军 李元贞 王多贤 陈欣 齐伟[2] 韩宪富 谢兴文 LIU Jianjun;LI Yuanzhen;WANG Duoxian;CHEN Xin;QI Wei;HAN Xianfu;XIE Xingwen(The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学附属医院,甘肃兰州730000 [2]甘肃中医药大学,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2023年第10期1523-1527,共5页Chinese Journal of Osteoporosis

基　　金：甘肃省卫生健康行业科研项目(GSWSKY-2021-009);兰州市城关区科技计划项目(2020-2-2-7);甘肃中医药大学附属医院院内创新基金(gzfy-2020-24);甘肃省科技计划资助(20JR5RA129);兰州市科技发展指导性计划项目(2022-20-91);甘肃省青年科技基金计划(20JR10RA345)。

摘　　要：骨关节炎(osteoarthritis,OA)作为慢性低度炎症性疾病,对它的研究一直是重点和难点,因此如何延缓OA的进展成为最主要的问题。miR-146a作为维持软骨稳态的关键调节因子,其表达的变化对软骨退变和炎症具有调节作用。Toll样受体4(toll-like receptor 4,TLR4)/核因子-κB(nuclear Factor-κB,NF-κB)信号通路通过调节免疫炎症反应,维持软骨代谢稳态。虽然miR-146a介导TLR4/NF-κB信号通路延缓OA已有研究,但是具体作用机制仍然不完善。本研究通过miR-146a介导TLR4/NF-κB信号通路对炎症及软骨细退变方面的综述,为OA的治疗提供理论依据和潜在分子靶标。Osteoarthritis(OA)is a chronic low-grade inflammatory disease.It has always been the focus and difficulty.How to delay the progress of OA has become the most important problem.As a key regulator to maintain cartilage homeostasis,miR-146a has a regulatory effect on cartilage degeneration and inflammation.Toll-like receptor 4(TLR4)/Nuclear Factor-κB(NF-κB)signaling pathway maintains the metabolic homeostasis of cartilage by regulating immune and inflammatory responses.Although it has been studied that miR-146a mediates TLR4/NF-κB signaling pathway to delay OA,the specific mechanism is still not perfectly understood.This study reviews the effects of miR-146a on inflammatory factors,chondrocyte apoptosis,and cartilage extracellular matrix degradation through TLR4/NF-κB signaling pathway,so as to provide theoretical basis and potential molecular targets for the treatment of OA.

关 键 词：骨关节炎 MIR-146A TLR4/NF-κB信号通路 研究进展 

分 类 号：R684[医药卫生—骨科学]