类风湿关节炎患者血清白细胞介素-39变化及临床意义  

Changes of serum interleukin-39 concentration in patients with rheumatoid arthritis and its clinical significance

作　　者：桂菲 楚金申[1] 潘京[1] 薛国辉[1] 梅寒颖 GUI Fei;CHU Jinshen;PAN Jing;XUE Guohui;MEI Hanying(Department of Clinical Laboratory,the First People′s Hospital of Jiujiang,Jiujiang,Jiangxi 332001,China;Department of Rheumatology and Immunology,the First People′s Hospital of Jiujiang,Jiujiang,Jiangxi 332001,China)

机构地区：[1]九江市第一人民医院检验科,江西九江332001 [2]九江市第一人民医院风湿免疫科,江西九江332001

出　　处：《现代医药卫生》2023年第21期3665-3668,共4页Journal of Modern Medicine & Health

基　　金：江西省卫生健康委员会科技计划项目支撑项目(202140262)。

摘　　要：目的探究白细胞介素-39(IL-39)在类风湿关节炎(RA)患者中的变化及临床价值。方法收集2019年1月至2021年8月该院收治的RA患者46例(RA组),另选取同期在该院健康体检者30例作为对照组。采用酶联免疫吸附试验测定血清IL-39水平,同时检测C反应蛋白、类风湿因子、抗环瓜氨酸抗体、红细胞沉降率等炎症指标,分析RA患者血清IL-39水平的变化及与疾病活动度的关系。结果RA组患者IL-39、类风湿因子、抗环瓜氨酸抗体、C反应蛋白、红细胞沉降率均明显高于对照组,且活动期患者血清IL-39水平明显高于稳定期患者,差异均有统计学意义(P<0.05);IL-39与疾病活动度评分28明显相关(r=0.6757,P<0.05)。结论IL-39在RA患者中表达异常且与疾病活动度相关,具有一定的临床辅助诊断价值。Objective To explore the changes and clinical value of interleukin-39(IL-39)in patients with rheumatoid arthritis(RA).Methods A total of 46 patients with RA admitted to this hospital from January 2019 to August 2021(RA group)were collected,and another 30 healthy patients in this hospital during the same period were selected as the control group.Serum IL-39 level was determined by ELISA,and inflammatory indexes such as C-reactive protein,rheumatoid factor,anti-cyclic citrulline antibody and erythrocyte sedimentation rate were detected.The changes of serum IL-39 in RA patients and its relationship with disease activity were analyzed.Results IL-39,rheumatoid factor,anti-cyclic citrulline peptide antibody,C-reactive protein and erythrocyte sedimentation rate in RA group were significantly higher than those in the control group,and serum IL-39 level in active patients was significantly higher than that in stable patients,the differences were statistically significant(P<0.05).IL-39 was significantly correlated with disease activity score 28(r=0.6757,P<0.05).Conclusion IL-39 expression is abnormal in RA patients and correlated with disease activity,which has a certain value in clinical auxiliary diagnosis.

关 键 词：类风湿关节炎 白细胞介素-39 C反应蛋白 类风湿因子 抗环瓜氨酸抗体 红细胞沉降率 

分 类 号：R593.22[医药卫生—内科学]