苯扎贝特片联合氨氯地平片治疗高血压合并血脂代谢紊乱患者的效果  

Effects of Benzafibrate tablets combined with Amlodipine tablets in treatment of hypertension complicated with dyslipidemia

作　　者：马翔 宋相为 王东玲 李峥 MA Xiang;SONG Xiangwei;WANG Dongling;LI Zheng(Department of Cardiology of Huaihe Hospital of Henan University,Kaifeng 475000 Henan,China)

机构地区：[1]河南大学淮河医院心血管内科,河南开封475000

出　　处：《中国民康医学》2023年第20期40-43,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察苯扎贝特片联合氨氯地平片治疗高血压合并血脂代谢紊乱患者的效果。方法:选取2019年3月至2022年3月该院收治的74例高血压合并血脂代谢紊乱患者进行前瞻性研究,根据随机数字表法将其分为研究组(n=37)和对照组(n=37)。对照组采用氨氯地平片治疗,研究组在对照组基础上联合苯扎贝特片治疗,比较两组临床疗效、治疗前后血压指标[收缩压(SBP)、舒张压(DBP)]水平、血脂指标[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平、血管内皮细胞功能指标[一氧化氮(NO)、内皮素-1(ET-1)]水平和不良反应发生率。结果:研究组治疗总有效率为94.59%(35/37),高于对照组的78.38%(29/37),差异有统计学意义(P<0.05);治疗后,研究组SBP、DBP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组HDL-C、NO水平均高于对照组,LDL-C、ET-1水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苯扎贝特片联合氨氯地平片治疗高血压合并血脂代谢紊乱患者可提高治疗总有效率,改善血脂指标和血管内皮细胞功能指标水平,降低血压指标水平,效果优于单纯氨氯地平片治疗。Objective:To observe effects of Benzafibrate tablets combined with Amlodipine tablets in treatment of patients with hypertension and dyslipidemia.Methods:A prospective study was conducted on 74 patients with hypertension and dyslipidemia admitted to the hospital from March 2019 to March 2022.They were divided into study group(n=37)and control group(n=37)according to the random number table method.The control group was treated with Amlodipine tablets,while the study group was treated with Benzafibrate tablets on the basis of that of the control group.The clinical efficacy,the blood pressure index levels[systolic blood pressure(SBP),diastolic blood pressure(DBP)],the blood lipid index levels[high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],the vascular endothelial cell function index levels[nitric oxide(NO),endothelin-1(ET-1)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 94.59%(35/37),which was higher than 78.38%(29/37)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of SBP and DBP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of HDL-C and NO in the study group were higher than those in the control group,and the levels of LDL-C and ET-1 were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Benzafibrate tablets combined with Amlodipine tablets in the treatment of the patients with hypertension and lipid metabolism disorders can improve the total effective rate of treatment,improve the levels of blood lipid indexes and vascular endothelial cell function indexes,and reduce the levels of blood pressure indexes.Moreover,

关 键 词：高血压 血脂代谢紊乱 苯扎贝特片 氨氯地平片 血脂 血压 内皮细胞 

分 类 号：R972[医药卫生—药品]