左氧氟沙星联合抗结核化疗方案在病原学阳性复治肺结核治疗中的应用效果  

Application Effect of Levofloxacin Combined with Anti-Tuberculosis Chemotherapy in Treatment of Retreatment Pulmonary Tuberculosis with Positive Etiology

作　　者：吴玉萍 王霞 Wu Yuping;Wang Xia(The Fourth People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750021,Ningxia Hui Autonomous Region,China)

机构地区：[1]宁夏回族自治区第四人民医院,宁夏回族自治区银川750021

出　　处：《中国社区医师》2023年第29期56-58,共3页Chinese Community Doctors

摘　　要：目的:探讨在病原学阳性复治肺结核患者的治疗中应用左氧氟沙星联合抗结核化疗方案的临床效果。方法:选取2021年1月—2022年7月宁夏回族自治区第四人民医院收治的120例病原学阳性复治肺结核患者作为研究对象,采用随机数字表法分为对照组与观察组,各60例。对照组接受常规抗结核化疗方案治疗,观察组在对照组基础上联合左氧氟沙星治疗。比较两组治疗效果。结果:观察组病灶总吸收率高于对照组,差异有统计学意义(P=0.040)。观察组空洞总改善率高于对照组,差异有统计学意义(P=0.030)。观察组痰涂片转阴率高于对照组,差异有统计学意义(P=0.016)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.026)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:左氧氟沙星联合抗结核化疗方案治疗病原学阳性复治肺结核的效果显著,可提高病灶吸收率、空洞改善率、痰涂片转阴率,且未增加不良反应发生率。Objective:To investigate the clinical effect of levofloxacin combined with anti-tuberculosis chemotherapy in the treatment of retreatment pulmonary tuberculosis patients with positive etiology.Methods:From January 2021 to July 2022,120 retreatment pulmonary tuberculosis patients with positive etiology admitted to The Fourth People's Hospital of Ningxia Hui Autonomous Region were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with conventional anti-tuberculosis chemotherapy,and the observation group was treated with levofloxacin on the basis of the control group.The treatment effects were compared between the two groups.Results:The total absorption rate of lesions in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.040).The total improvement rate of cavitation in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.030).The sputum smear negative conversion rate in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.016).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.026).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Levofloxacin combined with anti-tuberculosis chemotherapy has a significant effect in the treatment of retreatment pulmonary tuberculosis with positive etiology,which can increase the absorption rate of lesions,the rate of cavitation improvement,the rate of sputum smear negative conversion,and will not increase the incidence of adverse reactions.

关 键 词：复治肺结核 左氧氟沙星 抗结核化疗 病灶吸收 痰涂片 

分 类 号：R521[医药卫生—内科学]