沙库巴曲缬沙坦联合环磷腺苷治疗对急性左心衰竭患者炎性因子、心肌损伤标志物及心脏功能的影响  

The effect of rhBNP combined with sakubactria valsartan on cardiac function and neuroendocrine hormone levels in patients with acute heart failure

作　　者：李燕芳 刘峰 郭柱力 别发瀛 LI Yan-fang;LIU Feng;GUO Zhu-li(Department of Cardiovascular Medicine,Xingshan County People′s Hospital,Xingshan 443700,China;Department of Cardiovascular Medicine,Yichang Central People′s Hospital,Yichang 443000,China)

机构地区：[1]湖北省兴山县人民医院心血管内科,湖北兴山443700 [2]湖北省宜昌市中心人民医院心血管内科,湖北宜昌443000

出　　处：《吉林医学》2023年第11期3111-3114,共4页Jilin Medical Journal

基　　金：湖北省卫生健康委科研项目[项目编号:WJ2019Q016]。

摘　　要：目的:研究沙库巴曲缬沙坦联合环磷腺苷治疗对急性左心衰竭患者炎性因子、心肌损伤标志物及心脏功能的影响。方法:选取收治的80例急性左心衰竭患者作为研究对象,随机分为对照组与观察组各40例,其中对照组为常规治疗(强心、利尿、扩血管)+环磷腺苷治疗,观察组在对照组基础上联合沙库巴曲缬沙坦治疗,所有患者治疗周期为2 w。记录治疗前后炎性因子、心肌损伤标志物以及心功能指标变化情况,比较不同治疗方式的疗效以及统计低血压、高血钾等不良反应的发生次数。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清炎性因子指标、心肌损伤标志物指标降低;观察组炎性因子指标、心肌损伤标志物指标显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组左心室射血分数(LVEF)明显增加,心功能指标水平改善,并且观察组心功能各指标水平明显优于对照组,差异有统计学意义(P<0.05)。治疗期间两组急性左心衰竭患者的不良反应主要为低血压、高血钾等,不良反应发生率比较差异无统计学意义(P>0.05)。结论:沙库巴曲缬沙坦联合环磷腺苷治疗对急性左心衰竭患者可有效降低炎性因子水平,降低心肌损伤,改善心脏功能,临床疗效显著。Objective To investigate the effects of combined use of recombinant human brain natriuretic peptide(rhBNP)and sarcubatrixartan on cardiac function and neuroendocrine hormone levels in patients with acute heart failure(AHF).Method 80 AHF patients admitted to our hospital were selected as the study subjects.According to a simple randomization method,the study subjects were divided into an observation group of 40 cases and a control group of 40 cases.Both groups of patients were treated with vasodilators for blood pressure reduction,while the control group was treated with sacubatravalsartan on top of this medication.The observation group was treated with rhBNP on top of the control group,and the cardiac function indicators before and after treatment were compared between the two groups,The levels of neuroendocrine cytokines and inflammatory factors,as well as the differences in the incidence of adverse reactions between the two groups after medication.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,two groups of serum inflammatory response factor indicators and myocardial injury marker indicators decreased;The inflammatory response factor and myocardial injury marker indicators in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the left ventricular ejection fraction of the two groups significantly increased,and the level of cardiac function indicators improved.The observation group had significantly better levels of cardiac function indicators than the control group(P<0.05).During the treatment period,the main adverse reactions of the two groups of acute left heart failure patients were hypotension,hyperkalemia,etc.There was no statistically significant difference in the incidence of adverse reactions(P>0.05).Conclusion The combination of rhBNP and sakubactria valsartan therapy can effectively reduce the levels of inflammatory response factors,reduce myocardial damage,and i

关 键 词：沙库巴曲缬沙坦 环磷腺苷 急性左心衰竭 炎性因子 心肌损伤标志物 心脏功能 

分 类 号：R541.6[医药卫生—心血管疾病]