Septin蛋白功能的研究进展  

Research progress on function of Septin

作　　者：王二龙 张文婷(综述)[1] 宋嘉宁 王娟(审校)[1] WANG Erlong;ZHANG Wenting;SONG Jianing;WANG Juan(Department of Environment and Life,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学环境与生命学部,北京100124

出　　处：《中国生物制品学杂志》2023年第10期1263-1270,共8页Chinese Journal of Biologicals

基　　金：国家自然科学基金(91854115)。

摘　　要：Septin是一类存在于除高等植物外的真核生物中高度保守的GTP结合蛋白。不同亚型的Septin可通过异源多聚体的形式形成丝状或环状等更高级有序的结构发挥相应功能,可调控酵母出芽、细胞分裂等生理过程,并参与宿主细胞的防御反应。Septin的异常表达或突变与肿瘤和神经系统疾病的发生、发展密切相关。本文就Septin蛋白家族成员的生理功能、Septin对肿瘤和神经系统疾病发生发展的影响以及Septin在宿主免疫应答过程中的作用等作一综述。Septin is a highly conserved class of GTP-binding proteins found in eukaryotes other than higher plants.The different subtypes of Septin can form higher order structures such as filamentous or ring-like structures in the form of heterodimer to perform their functions,which can regulate physiological processes such as yeast budding and cell division,as well as participating in the defense response of the host cell.Abnormal expression or mutation of Septin is closely related to the occurrence and development of tumors and neurological diseases.This paper summarized the physiological functions of the Septin family,the effects of Septin on the occurrence and development of tumors and neurological diseases,and the role of Septin in the host immune response.

关 键 词：SEPTIN 结合蛋白 生理功能 细胞支架 

分 类 号：Q257[生物学—细胞生物学]