毛囊微型化发生的机制与最新研究进展  

Mechanism of hair follicle miniaturization and update progress

作　　者：李潇 雷铁池[1] LI Xiao;LEI Tiechi(Department of Dermatology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院皮肤科,湖北武汉430060

出　　处：《南京医科大学学报（自然科学版）》2023年第11期1610-1616,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81972919)。

摘　　要：雄激素性脱发(androgenetic alopecia,AGA)又称为脂溢性脱发,是临床上最常见的脱发类型,毛囊微型化是该病发生发展过程中的重要特征。目前研究已发现有很多原因可诱导毛囊微型化的发生,一方面通过促使患者头皮毛囊真皮乳头细胞(dermal papilla cell,DPC)分泌毛囊抑制因子、DPC发生凋亡和自噬障碍,另一方面通过毛周微循环形成障碍、毛囊干细胞的过度耗竭及真皮鞘细胞的丢失与纤维化进一步加剧了AGA的发生发展,最终导致患者的毛发由最初的终毛逐渐转换为细小的毳毛。本综述从不同角度探讨毛囊微型化的病因与机制,为未来对AGA的有效治疗提供帮助。Androgenic alopecia(AGA),also termed as seborrheic alopecia,is the most common type of clinical alopecia,and the hair follicle miniaturization acts as a main clinical manifestation of AGA.Currently it has been considered that many reasons can induce hair follicle miniaturization.On the one hand,they promote dermal papilla cells of scalp hair follicle to secrete hair follicle inhibitory factor,and to have apoptosis and autophagy disorder;on the other hand,they destroy microvasculature surrounding the dermal papilla,and also cause depletion and fibrosis of hair follicle stem cells and dermal sheath cells,eventually causing the gradual transition from the initial terminal hair to thin pili.This review discusses the update mechanism of hair follicle miniaturization resulting from distinct type of hair negative factors and holds substantial promise for the future treatment of AGA.

关 键 词：二氢睾酮 真皮乳头 毛囊微型化 毛囊干细胞 

分 类 号：R753.3[医药卫生—皮肤病学与性病学]