Clinical epidemiology and disease burden of bronchiolitis in hospitalized children in China:a national cross-sectional study  

作　　者：Jiao Tian Xin‑Yu Wang Lin‑Lin Zhang Meng‑Jia Liu Jun‑Hong Ai Guo‑Shuang Feng Yue‑Ping Zeng Ran Wang Zheng‑De Xie 

机构地区：[1]Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Research Unit of Critical Infection in Children,Chinese Academy of Medical Sciences,2019RU016,Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Nan Li Shi Lu 56#,Beijing 100045,China [2]Big Data Center,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing,China [3]Medical Record Management Ofce,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing,China

出　　处：《World Journal of Pediatrics》2023年第9期851-863,共13页世界儿科杂志（英文版）

基　　金：XZD was supported by the CAMS Innovation Fund for Med‑ical Sciences(2019-I2M-5-026);the National Major Science&Technology Project(2017ZX10103004-004).

摘　　要：Background Bronchiolitis is a common acute lower respiratory tract infection(ALRTI)and the most frequent cause of hospitalization of infants and young children with ALRTI.Respiratory syncytial virus is the main pathogen that leads to severe bronchiolitis.The disease burden is relatively high.To date,few descriptions of the clinical epidemiology and disease burden of children hospitalized for bronchiolitis are available.This study reports the general clinical epidemiological characteristics and disease burden of bronchiolitis in hospitalized children in China.Methods This study included the face sheet of discharge medical records collected from 27 tertiary children’s hospitals from January 2016 to December 2020 that were aggregated into the FUTang Update medical REcords(FUTURE)database.The sociodemographic variables,length of stay(LOS)and disease burden of children with bronchiolitis were analyzed and compared using appropriate statistical tests.Results In total,42,928 children aged 0–3 years were hospitalized due to bronchiolitis from January 2016 to December 2020,accounting for 1.5%of the total number of hospitalized children of the same age in the database during the period and 5.31%of the hospitalizations for ALRTI.The male to female ratio was 2.01:1.Meanwhile,more boys than girls were observed in different regions,age groups,years,and residences.The 1–2 year age group had the greatest number of hospitalizations for bronchiolitis,while the 29 days–6 months group had the largest proportion of the total inpatients and inpatients with ALRTI in the same age group.In terms of region,the hospitalization rate of bronchiolitis was the highest in East China.Overall,the number of hospitalizations from 2017 to 2020 showed a decreasing trend from that in 2016.Seasonally,the peak hospitalizations for bronchiolitis occurred in winter.Hospitalization rates in North China in autumn and winter were higher than those in South China,while hospitalization rates in South China were higher in spring and summer.Approximately

关 键 词：BRONCHIOLITIS CHILDREN Clinical epidemiology Disease burden Respiratory syncytial virus 

分 类 号：R72[医药卫生—儿科]