Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale,near-infrared spectroscopy,and ultrasonography:a randomized trial  

作　　者：Nursu Kara Didem Arman Zeynep Seymen Adem Gül Serdar Cömert 

机构地区：[1]Department of Pediatrics,Division of Neonatology,University of Health Sciences Istanbul Research and Training Hospital,Istanbul,Turkey [2]Department of Opthalmology,University of Health Sciences Istanbul Research and Training Hospital,Istanbul,Turkey

出　　处：《World Journal of Pediatrics》2023年第9期873-882,共10页世界儿科杂志（英文版）

摘　　要：Background This study aimed to compare the efficacy of intravenous,intranasal fentanyl and oral sucrose in reducing the pain response during retinopathy of prematurity examinations using premature infant pain profile(PIPP)scores.Method The study included 42 infants who underwent retinopathy screening examinations.The infants were divided into three groups:oral sucrose,intranasal fentanyl,and intravenous fentanyl.Vital signs(heart rate,arterial oxygen saturation,and mean arterial pressure)were recorded.The PIPP was used to determine pain severity.Cerebral oxygenation and middle cerebral artery blood flow were evaluated using near-infrared spectroscopy and Doppler ultrasonography,respectively.The data obtained were compared between groups.Results There was no significant difference between the three groups regarding postconceptional and postnatal ages or birth weights and weight at the time of examination.All babies had moderate pain during the examination.No correlation was observed between analgesia method and pain scores(P=0.159).In all three groups,heart rate and mean arterial pressure increased,whereas oxygen saturation decreased during the exam compared with pre-examination values.However,heart rate(HR),mean arterial pressure(MAP)and arterial oxygen saturation(sPO2)values did not differ between groups(HR,P=0.150;MAP,P=0.245;sPO2,P=0.140).The cerebral oxygenation(rSO2)values between the three groups were found to be similar[rSO2:P=0.545,P=0.247,P=0.803;fractional tissue oxygen extraction(FTOE):P=0.553,P=0.278].Regarding cerebral blood flow values,we also did not find any difference between the three groups[mean blood flow velocity(Vmean):P=0.569,P=0.975;maximum flow velocity(Vmax):P=0.820,P=0.997].Conclusions Intravenous and intranasal fentanyl and oral sucrose were not superior to each other in preventing pain during the examination for retinopathy of prematurity(ROP).Sucrose may be a good alternative for pain control during ROP examination.Our findings suggest that ROP exam may not affect cerebral oxygenatio

关 键 词：ANALGESIA Cerebral blood flow Cerebral oxygenation NEONATE Retinopathy of prematurity 

分 类 号：R61[医药卫生—外科学]