Maternal and neonatal blood vitamin D status and neurodevelopment at 24 months of age:a prospective birth cohort study  

作　　者：Yue Zhang Chun-Yan Zhou Xi-Rui Wang Xian-Ting Jiao Jun Zhang Ying Tian Luan-Luan Li Chen Chen Xiao-Dan Yu 

机构地区：[1]Department of Developmental and Behavioral Pediatrics,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [2]Translational Medicine Institute,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [3]MOE-Shanghai Key Lab of Children’s Environmental Health,Xinhua Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200092,China

出　　处：《World Journal of Pediatrics》2023年第9期883-893,共11页世界儿科杂志（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2022YFC2705203);the National Natural Science Foundation of China(No.81773411);the Special Program for Women and Children Health(No.2020YJZX0212);Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(No.20152220);the Cultivation Project of Clinical Research from SCMC(No.LY-SCMC2020-06);Shanghai Children’s Health Services Capacity Program(No.GDEK201708);the Key Program for Clinical Nutrition(No.2019ZB0103)from Shanghai Municipal Health Commission.

摘　　要：Background This study aimed to explore the relationship of 25-hydroxyvitamin D[25(OH)D]in three trimesters and at birth with neurodevelopment at 24 months of age.Methods From 2013 to 2016,pregnant women from the Shanghai Birth Cohort in China were recruited for the study.Altogether,649 mother-infant pairs were included.Serum 25(OH)D was measured with mass spectrometry in three trimesters,and cord blood was divided into deficiency(<20 and<12 ng/mL,respectively),insufficiency(20–30 and 12–20 ng/mL,respectively),and sufficiency(≥30 and≥20 ng/mL,respectively).Bayley-III scale was used to assess cognitive,language,motor,social-emotional,and adaptive behavior development at 24 months of age.The Bayley-III scores were grouped into quartiles,and scores within the lowest quartile were defined as suboptimal development.Results After adjusting for confounding factors,cord blood 25(OH)D in the sufficient group was positively correlated with cognitive[β=11.43,95%confidence interval(CI)=5.65–17.22],language(β=6.01,95%CI=1.67–10.3),and motor scores(β=6.43,95%CI=1.73–11.1);cord blood 25(OH)D in the insufficient group was also positively correlated with cognitive scores(β=9.42,95%CI=3.74–15.11).Additionally,sufficient vitamin D status in the four periods and persistent 25(OH)D≥30 ng/mL throughout pregnancy were associated with a lower risk of suboptimal cognitive development in adjusted models,although the effects were attenuated after applying the false discovery rate adjustment.Conclusions Cord blood 25(OH)D≥12 ng/mL has a significant positive association with cognitive,language,and motor development at 24 months of age.Sufficient vitamin D status in pregnancy might be a protective factor for suboptimal neurocognition development at 24 months of age.

关 键 词：25-hydroxyvitamin D Children’s neurodevelopment Cord blood Maternal vitamin D status 

分 类 号：H31[语言文字—英语]