舒芬太尼联合罗哌卡因对高龄产妇无痛分娩分娩结局及母婴血清NO、皮质醇水平的影响  

Effects of Sufentanil Combined with Ropivacaine on Delivery Outcome of Painless Delivery and Maternal and Infant Serum NO and Cortisol Levels in Elderly Parturient Women

作　　者：周伟亚 李刚 ZHOU Weiya;LI Gang(Department of Anesthesiology,Xiangcheng Hospital of Traditional Chinese Medicine,Xiangcheng 466200,Henan,China)

机构地区：[1]项城市中医院麻醉科,河南项城466200

出　　处：《中国药物滥用防治杂志》2023年第10期1706-1709,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨舒芬太尼联合罗哌卡因对高龄产妇无痛分娩分娩结局与母婴NO、皮质醇水平的影响。方法:回顾性分析2019年11月—2021年11月我院收治的92例无痛分娩产妇的临床资料,按不同镇痛方式分为观察组(n=47)与对照组(n=45)。观察组给予舒芬太尼联合罗哌卡因镇痛,对照组给予罗哌卡因镇痛。比较两组镇痛效果、妊娠结局及产妇与新生儿娩出后胎儿血清一氧化氮(NO)、皮质醇(COR)水平。结果:观察组镇痛总有效率高于对照组,差异有统计学意义(P<0.05);两组器械助产与胎心异常发生率比较,差异无统计学意义(P>0.05);观察组剖宫产发生率与产后24h出血量低于对照组,差异有统计学意义(P<0.05)。两组各时间点NO水平比较,差异无统计学意义(P>0.05);观察组镇痛后1 h COR水平低于对照组,差异有统计学意义(P<0.05);两组新生儿娩出后COR水平低于同组镇痛后1 h时且观察组低于对照组,差异有统计学意义(P<0.05)。结论:高龄产妇无痛分娩时选择舒芬太尼与罗哌卡因联合镇痛效果显著,不仅可提高自然分娩率,还可降低NO与COR水平,对母婴发展均有利。Objective:To investigate the effects of sufentanil combined with ropivacaine on the outcome of painless delivery and the levels of NO and cortisol in maternal and infant.Methods:The clinical data of 92 parturients with painless delivery admitted to our hospital from November 2019 to November 2021 were retrospectively analyzed.They were divided into observation group(n=47)and control group(n=47)according to different analgesia methods.The observation group was given sufentanil combined with ropivacaine for analgesia,and the control group was given ropivacaine for analgesia.The analgesic effect,pregnancy outcome and fetal serum nitric oxide(NO)and cortisol(COR)levels after delivery were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of birth assisted by instruments and abnormal fetal heart rate between the two groups(P>0.05).The incidence of cesarean section and 24h postpartum blood loss in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was NO significant difference in NO level between the two groups at each time point(P>0.05).The level of 1 hCOR in the observation group after analgesia was lower than that in the control group,and the difference was statistically significant(P<0.05).The COR level of neonates in the two groups after delivery was lower than that in the same group 1 h after analgesia,and the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Sufentanil combined with ropivacaine has significant analgesic effect during painless delivery,which can not only improve the rate of natural delivery,but also reduce the level of NO and COR,effectively prevent neonatal asphyxia,which is beneficial to the development of mother and baby.

关 键 词：舒芬太尼 罗哌卡因 高龄产妇 分娩镇痛 

分 类 号：R714.3[医药卫生—妇产科学]