不同剂量氨溴索注射液治疗COPD伴肺部感染患者的效果  

Effect of Different Doses of Ambroxol Injection in the Treatment of COPD Patients with Pulmonary Infection

作　　者：杨迎春 郭宏杰[1] YANG Yingchun;GUO Hongjie(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院呼吸与危重症医学科,河南南阳473000

出　　处：《中国药物滥用防治杂志》2023年第10期1744-1747,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨不同剂量氨溴索注射液治疗COPD伴肺部感染患者的效果。方法:选取本院2021年1月—2022年12月接诊的80例COPD伴肺部感染患者作为研究对象。按照氨溴索注射液剂量的不同分为对照组和观察组,各40例。对照组采用15 mg氨溴索注射液静脉滴注,观察组采用30 mg氨溴索注射液静脉滴注,比较两组治疗效果、临床症状、炎症因子及不良反应发生情况。结果:研究组总有效率为95.00%,高于对照组的77.50%(P<0.05);治疗后,两组咳嗽、痰液性质、呼吸困难以及肺部啰音评分低于治疗前,且研究组低于对照组(P<0.05);治疗后,两组TNF-α、CRP、ANC水平低于治疗前,且研究组低于对照组(P<0.05);研究组不良反应发生率低于对照组(P<0.05)。结论:30 mg氨溴索注射液治疗COPD伴肺部感染的疗效确切,可以改善患者的临床症状,降低炎症水平,安全性好。Objective:To explore the efficacy of different doses of ambroxol injection in the treatment of COPD patients with pulmonary infection.Methods:A total of 80 COPD patients with pulmonary infection who were admitted to our hospital from January 2021 to December 2022 were selected as the research objects.According to the different doses of ambroxol injection,they were divided into control group and observation group,with 40 cases in each group.The control group was treated with 15 mg ambroxol injection,and the observation group was treated with 30 mg ambroxol injection.The therapeutic effect,clinical symptoms,inflammatory factors and adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.00%,which was higher than 77.50%of the control group(P<0.05).After treatment,the scores of cough,sputum nature,dyspnea and pulmonary rales in the two groups were lower than those before treatment,and those in the study group were lower than the control group(P<0.05).After treatment,the levels of TNF-α,CRP and ANC in the two groups were lower than those before treatment,and those in the study group were lower than the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion:30 mg ambroxol injection is effective in the treatment of COPD with pulmonary infection,which can improve the clinical symptoms of patients,reduce the level of inflammation,and has good safety.

关 键 词：氨溴索注射液 炎症因子 临床症状 不良反应 

分 类 号：R563[医药卫生—呼吸系统]