海参牛磺酸胶囊对小鼠免疫功能的影响  

Effect of sea cucumber taurine capsule on immune function of mice

作　　者：刘英华[1] 张书婧[1] 张静[1] 周殿明[1] 周庆红[1] 钱智勇[1] LIU Yinghua;ZHANG Shujing;ZHANG Jing;ZHOU Dianming;ZHOU Qinghong;QIAN Zhiyong(Sanitary Inspection&Testing Institute,Tianjin Centers for Disease Control and Prevention,Tianjin,300011,China)

机构地区：[1]天津市疾病预防控制中心卫生检验检测所,天津300011

出　　处：《职业与健康》2023年第18期2490-2493,共4页Occupation and Health

摘　　要：目的 对海参牛磺酸胶囊的免疫功能进行研究。方法 采用迟发型变态反应试验、脾淋巴细胞转化试验、半数溶血值试验、抗体生成细胞检测试验、碳廓清试验、腹腔巨噬鸡红细胞试验等方法,探讨海参牛磺酸胶囊增强小鼠免疫力作用。结果 高剂量组海参牛磺酸胶囊促进刀豆蛋白A(concanavalin A,ConA)诱导的脾T淋巴细胞转化反应,高剂量组为0.248±0.034,对照组为0.198±0.026,差异有统计学意义(P<0.05);中剂量和高剂量组小鼠足跖厚度差值分别为(0.74±0.23)、(0.74±0.17)mm,与对照组[(0.48±0.16)mm]比较,差异均有统计学意义(均P<0.05);高剂量组半数溶血值(278.3±16.2)较对照组(247.4±12.4)的高,中剂量组抗体生成细胞数[(33.4±4.9)×10^(3)个]较对照组[(28.1±3.8)×10^(3)个]增加,差异均有统计学意义(均P<0.05)。结论 海参牛磺酸胶囊具有提高小鼠免疫力的功能。Objective To investigate the immune function of sea cucumber taurine capsules.Methods The effects of sea cucumber taurine capsules on immunity of mice were investigated by delayed allergic reaction,spleen lymphocyte transformation,half haemolysis value,antibody-producing cell test,carbon profiling test and peritoneal macrophagy of chicken red blood cells.Results The concanavalin A(ConA)-induced proliferation of spleen T lymphocytes was promoted by high dose sea cucumber taurine capsules,which was 0.248±0.034 in the high dose group and 0.198±0.026 in the control group,and the difference was statistically significant(P<0.05).The values of planta swelling in the middle and high dose groups was(0.74±0.23)and(0.74±0.17)mm respectively,which was statistically significant compared with the control group[(0.48±0.16)mm](P<0.05).The half hemolytic value in the high dose group(278.3±16.2)was higher than that in the control group(247.4±12.4),and number of antibody producing cells in the middle dose group[(33.4±4.9)×10^(3) cells]was higher than that in the control group[(28.1±3.8)×10^(3) cells](P<0.05).Conclusion The sea cucumber taurine capsule can improve the immune function of mice.

关 键 词：海参牛磺酸胶囊 免疫力功能 小鼠 

分 类 号：R285.5[医药卫生—中药学]