膀胱平滑肌细胞表型转化和膀胱功能障碍的相关研究进展  

Phenotypic transformation of bladder smooth muscle cells and bladder dysfunction:A review

作　　者：赵凡 叶妙勇 张春和 颜俊锋 Zhao Fan;Ye Miaoyong;Zhang Chunhe;Yan Junfeng(Department of Urology,Affiliated Hospital of Nantong University,Nantong 226001,China;Department of Urology,the Affiliated Wenling Hospital of Wenzhou Medical University,Wenling 317500,China;Department of Urology and Andrology,the First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China;Department of Urology,Affiliated Zhejiang Hospital,Zhejiang University School of Medicine,Hangzhou 310030,China)

机构地区：[1]南通大学附属医院泌尿外科,南通226001 [2]温州医科大学附属温岭医院泌尿外科,温岭317500 [3]云南中医药大学第一附属医院泌尿男科,昆明650021 [4]浙江大学医学院附属浙江医院泌尿外科,杭州310030

出　　处：《中华实验外科杂志》2023年第9期1879-1884,共6页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(82104855、81860853、82004360);南通市基础科学研究青年科技人才创新专项(JC12022077);台州市社会发展类科技计划项目(22ywb130)。

摘　　要：膀胱平滑肌细胞(BSMC)是一种功能可塑性的细胞,通过测定不同状态下细胞所表达的优势蛋白,可将其区分为"收缩表型"或"合成表型"。BSMC表型转化和膀胱功能障碍(BD)密切相关,即由"收缩表型"向"合成表型"转化。本文将就BSMC表型的概念、分子标志物研究和不同类型致病因素相关BD与BSMC表型转化的内在联系等方面进行梳理与阐释,结合已有的研究成果,展望调节BSMC表型转化在BD诊治领域的应用潜力。Bladder smooth muscle cells(BSMCs)are one kind of functional plastic cells.By measuring the dominant protein expressed by the cells in different states,they can be divided into"contractive phenotype"or"synthetic phenotype".Bladder dysfunction(BD)is closely related to the BSMCs phenotypic transformation:from"contractive phenotype"to"synthetic phenotype".This article will sort out and explain the concept of BSMCs phenotype,the study of molecular markers,and the internal relationship between BD and BSMCs phenotypic transformation related to different types of pathogenic factors.Combining with the existing research results,it will look forward to the application potential of regulating BSMCs phenotypic transformation in the field of LUTS diagnosis and treatment.

关 键 词：膀胱平滑肌细胞 表型转化 膀胱功能障碍 下尿路症状 

分 类 号：R694[医药卫生—泌尿科学]