Recent advances in annulations enabled by nucleophilic Lewis base/metal dual catalysis  

作　　者：Qian Wang Yinggao Meng Lulu Wu Er-Qing Li 

机构地区：[1]College of Chemistry,Green Catalysis Center,Zhengzhou University,Zhengzhou 450001,China [2]School of Science,Henan Agricultural University,Zhengzhou 450002,China

出　　处：《Chinese Chemical Letters》2023年第10期12-26,共15页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.21702189);the Key Scientific and Technological Project of Henan Province(No.202102310004);Science and Technology Research and Development Plan Joint Fund(cultivation of superior disciplines)Project(No.222301420042);Zhengzhou University(No.JC21253007)of China for financial support of this research.

摘　　要：Metal/nucleophilic Lewis base dual catalysis has been recognized as a reliable and promising strategy for finishing ideal organic synthesis over the past decades.The new strategy can usually achieve some chemical reactions that cannot be realized by the traditionally mono-catalytic system,dramatically expanding the synthetic utility of chemical transformations by leveraging additional activation modes.Thus considerable progress has been made in the synthesis of a wide range of heterocyclic and biologically active compounds by using the combination of diversely metal/nucleophilic Lewis base dual catalysts,including metal/phosphine,metal/N-heterocyclic carbene(NHC)and metal/tertiary amine dual catalysis systems.In this review,we describe a comprehensive and updated advance of metal/nucleophilic Lewis base dual catalytic annualtion reactions,meanwhile,the related mechanism and the application of these annulation strategies in natural product total synthesis will be highlighted in detail.

关 键 词：Lewis base Metal catalysis Annualtion Dual catalysis Synthetic methods 

分 类 号：O621.251[理学—有机化学]