A trans-ortho asymmetrically di-strapped metalloporphyrin integrating three key structural features of ligand in heme  

作　　者：Qiuhua Liu Junhao Gao Yusheng Zhang Xin Liu Xi Zhang Qin Lin Wennan Zeng Zaichun Zhou 

机构地区：[1]Key Laboratory of Theoretical Organic Chemistry and Functional Molecules,Ministry of Education [2]School of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan 411201,China

出　　处：《Chinese Chemical Letters》2023年第10期140-145,共6页中国化学快报（英文版）

基　　金：supported by the Institute of Elemento-organic Chemistry,Nankai University and the Scientific Research Fund of Hunan Provincial Education Department(No.20A195);Hunan Provincial Natural Science Foundation of China(No.2020JJ4292);the Science and Technology innovation Program of Hunan Province(No.2021RC5028).

摘　　要：Heme responsible for the dioxygen fixation,transport and conversion is a metalloporphyrin complex highly dependent on its diverse geometry of ligand.In this work,a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of transprecursor of porphyrinogen.Its single-crystal structure demonstrated that the asymmetric treatment of porphyrin achieves three goals of creating two secondary coordination sphere(SCS)bulks,maintaining a unique dome deformation,and making atomic out-of-plane deviation.In this way,this metallic complex integrates at least three key features of the pocket structure,the differentiated axial ligations,and the ring distortion,making it an ideal heme analog.

关 键 词：Supramolecular effect Heme analog Pocket effect Axial ligation Ring distortion 

分 类 号：O626[理学—有机化学]