An integrated supramolecular fungicide nanoplatform based on pH-sensitive metal–organic frameworks  

作　　者：Chao-Yi Wang Yu-Qing Liu Chengguo Jia Ming-Zhe Zhang Chun-Li Song Changling Xu Ran Hao Jian-Chun Qin Ying-Wei Yang 

机构地区：[1]College of Chemistry,Jilin University,Changchun 130012,China [2]College of Plant Science,Jilin University,Changchun 130062,China

出　　处：《Chinese Chemical Letters》2023年第10期153-158,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.52173200,31470414,31870332);the Natural Science Foundation of Jilin Province(No.20230101052JC);the Special Fund Project of Shenzhen City for Local Science and Technology Development Guided by the Central Government(No.2021Szvup049);the National Major Increase or Decrease Project-Construction of the sustainable utilization capacity of famous traditional Chinese medicine resources(No.2060302);the Fundamental Research Funds for the Central Universities(No.2022-JCXK-13)。

摘　　要：The construction of an integrated nanoplatform with controlled fungicide delivery features in the specific microenvironment produced by fungal pathogens is a highly desirable strategy to improve the utilization of fungicides. Herein, we report a supramolecular fungicide delivery system based on benzimidazolemodified NH_(2)-MIL-101(Fe) metal–organic frameworks(B-MIL-101(Fe) MOFs) as carriers loaded with osthole(OS), and β-cyclodextrin(β-CD) as nanovalves to form β-CD@B-MIL-101(Fe)-OS. The nanoplatform can release the loaded OS for fungus control through self-degradation of the MOFs skeleton in an oxalic acid microenvironment produced by Botrytis cinerea. The experimental results exhibit that the constructed supramolecular fungicide delivery system could effectively inhibit mycelial growth and protect the tomatoes from infection by B. cinerea during the ripening stage. This strategy constructs a facile and integrated supramolecular drug delivery system for B. cinerea control and opens up a new avenue for the sustainable development of modern agriculture.

关 键 词：Controlled release Fungicidenanoplatform Host-guest chemistry Microenvironment-responsive Supramolecularchemistry 

分 类 号：TQ450.42[化学工程—农药化工] TB383.1[一般工业技术—材料科学与工程]