小儿腹泻应用锌剂联合叶酸治疗的临床价值分析  

Analysis of the clinical value of zinc combined with folic acid in the treatment of diarrhea in children

作　　者：肖永伟 XIAO Yong-wei(Youxi General Hospital,Sanming 365100,China)

机构地区：[1]尤溪县总医院,365100

出　　处：《中国现代药物应用》2023年第20期106-109,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析小儿腹泻应用锌剂联合叶酸治疗的临床价值。方法70例腹泻患儿,按照住院号单双法随机分为对照组和观察组,每组35例。对照组给予常规补液等疗法治疗,观察组在对照组基础上增加锌剂联合叶酸治疗。比较两组症状改善时间(排便正常时间、脱水纠正时间、饮食恢复正常时间、精神状态恢复良好时间),治疗前后症状积分、免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、机体炎症指标[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)],治疗效果及不良反应发生情况。结果观察组排便正常时间、脱水纠正时间、饮食恢复正常时间、精神状态恢复良好时间分别为(1.34±0.21)、(1.19±0.21)、(3.21±0.23)、(3.19±0.21)d,均短于对照组的(3.51±1.21)、(3.25±0.45)、(5.56±1.02)、(5.25±1.18)d(P<0.05)。治疗后,两组症状积分与本组治疗前对比均显著降低,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)与本组治疗前对比均显著升高,且观察组症状积分(0.64±0.12)分低于对照组的(1.21±0.14)分,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)分别为(78.91±5.21)%、(44.08±2.32)%、(1.98±0.26),均明显高于对照组的(63.21±4.92)%、(36.08±2.32)%、(1.23±0.26)(P<0.05)。治疗后,两组TNF-α、hs-CRP、IL-6均明显低于本组治疗前,且观察组TNF-α、hs-CRP、IL-6分别为(1.56±0.21)ng/L、(7.19±1.02)mg/L、(61.22±2.16)pg/ml,明显低于对照组的(2.45±0.28)ng/L、(9.22±1.56)mg/L、(121.41±2.11)pg/ml(P<0.05)。观察组总有效率94.29%高于对照组的74.29%(P<0.05)。两组治疗中均无不良反应。结论在常规补液等疗法基础上给予锌剂联合叶酸治疗小儿腹泻疗效确切,可有效改善患儿腹泻症状,提高机体免疫功能,值得推广。Objective To analyze the clinical value of zinc combined with folic acid in the treatment of diarrhea in children.Methods A total of 70 children with diarrhea were randomly divided into control group and observation group according to odd-even hospitalization number method,with 35 cases in each group.The control group was given conventional rehydration therapy,and the observation group was given zinc combined with folic acid on the basis of the control group.Both groups were compared in terms of time to symptom improvement(time to normal defecation,time to dehydration correction,time to normal diet,time to good mental state),symptom score,immune function indicators(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)),inflammatory indicators[tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)]before and after treatment,therapeutic effect,and occurrence of adverse reactions.Results The time to normal defecation,the time to dehydration correction,the time to normal diet and the time to good mental state in the observation group were(1.34±0.21),(1.19±0.21),(3.21±0.23)and(3.19±0.21)d,which were shorter than those of(3.51±1.21),(3.25±0.45),(5.56±1.02)and(5.25±1.18)d in the control group(P<0.05).After treatment,the symptom score in both groups were significantly lower than that before treatment in this group,and CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were significantly higher than those before treatment in this group;the symptom score of(0.64±0.12)points in the observation group was lower than that of(1.21±0.14)points in the control group;CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were(78.91±5.21)%,(44.08±2.32)%,(1.98±0.26)in the observation group,which were significantly higher than those of(63.21±4.92)%,(36.08±2.32)%,(1.23±0.26)in the control group(P<0.05).After treatment,TNF-α,hs-CRP and IL-6 in both groups were significantly lower than those before treatment in this group;in the observation group,TNF-α,hs-CRP and IL-6 were(1.56±0.21)ng/L,(7.19±1.02)mg/L and(61.22±2.16)pg/ml,which were signifi

关 键 词：小儿腹泻 锌剂 叶酸 炎症因子 

分 类 号：R725.7[医药卫生—儿科]