N-乙酰半胱氨酸雾化吸入治疗门诊急性鼻窦炎的临床疗效探讨  

Clinical efficacy of N-acetylcysteine inhalation in outpatient treatment of acute sinusitis

作　　者：陈海兴 CHEN Hai-xing(Chongren County People's Hospital,Fuzhou 344200,China)

机构地区：[1]崇仁县人民医院,344200

出　　处：《中国现代药物应用》2023年第20期120-122,共3页Chinese Journal of Modern Drug Application

摘　　要：目的研究门诊急性鼻窦炎患者应用N-乙酰半胱氨酸雾化吸入治疗的临床疗效。方法64例门诊急性鼻窦炎患者作为研究对象,采用抽签方式分为实验组及对照组,每组32例。对照组采用盐酸左西替利嗪片治疗,实验组在对照组基础上加用N-乙酰半胱氨酸雾化吸入治疗。比较两组患者临床疗效,不良反应发生情况,治疗前后嗅觉减退评分和呼吸不畅评分,满意度。结果实验组患者的治疗总有效率96.88%明显高于对照组的62.50%,差异具有统计学意义(P<0.05)。实验组患者不良反应发生率9.38%(3/32)低于对照组的31.25%(10/32),差异具有统计学意义(χ^(2)=11.972,P=0.001<0.05)。实验组患者治疗后嗅觉减退评分为(1.36±0.42)分、呼吸不畅评分为(2.36±0.42)分,均低于对照组的(4.36±0.41)、(5.21±0.31)分,差异具有统计学意义(t=28.914、30.884,P=0.000、0.000<0.05)。实验组患者总满意度为96.88%,高于对照组的65.63%,差异具有统计学意义(χ^(2)=10.256,P=0.001<0.05)。结论N-乙酰半胱氨酸雾化吸入治疗门诊急性鼻窦炎患者的效果极佳,能够提高患者的治疗满意度,降低不良反应的发生率,值得在临床上大范围推广。Objective To study the clinical efficacy of N-acetylcysteine inhalation in outpatient treatment of acute sinusitis.Methods A total of 64 outpatient patients with acute sinusitis were divided into experimental group and control group by lottery method,with 32 cases in each group.The control group was treated with levocetirizine hydrochloride tablets,and the experimental group was treated with N-acetylcysteine inhalation on the basis of the control group.The clinical efficacy,occurrence of adverse reactions,anosmia score and dyspnea score before and after treatment,and satisfaction were compared between the two groups.Results The total effective rate of 96.88%in the experimental group was significantly higher than that of 62.50%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 9.38%(3/32),which was lower than that of 31.25%(10/32)in the control group,and the difference was statistically significant(χ^(2)=4.730,P=0.030<0.05).After treatment,the anosmia score of(1.36±0.42)points and dyspnea score of(2.36±0.42)points in the experimental group were lower than those of(4.36±0.41)and(5.21±0.31)points in the control group,and the differences were statistically significant(t=28.914,30.884;P=0.000,0.000<0.05).The total satisfaction of patients in the experimental group was 96.88%,which was higher than that of 65.63%in the control group,and the difference was statistically significant(χ^(2)=10.256,P=0.001<0.05).Conclusion N-acetylcysteine inhalation has an excellent therapeutic effect on outpatients with chronic sinusitis.It can improve the treatment satisfaction of patients and reduce the occurrence of adverse reactions,and is worthy to be popularized in clinic.

关 键 词：N-乙酰半胱氨酸雾化吸入 急性鼻窦炎 盐酸左西替利嗪片 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]