四妙散加减结合针刺治疗下焦湿热型慢性前列腺炎疗效观察  

Effect of modified Simiao Powder combined with acupuncture in the treatment of chronic prostatitis of lower-Jiao damp-heat syndrome

作　　者：翟建丽 王金会 丁新菊 裴强[1] 郭妍 赵习德[1] ZHAI Jian-li;WANG Jin-hui;DING Xin-ju;PEI Qiang;GUO Yan;ZHAO Xi-de(Department of Integrated Traditional Chinese and Western Medicine,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,Henan,CHINA)

机构地区：[1]新乡医学院第一附属医院中西医结合科,河南新乡453100

出　　处：《海南医学》2023年第21期3078-3082,共5页Hainan Medical Journal

基　　金：河南省卫生健康委员会中医药传承与创新人才工程(编号:210999904)。

摘　　要：目的观察四妙散加减结合针刺治疗下焦湿热型慢性前列腺炎的临床效果。方法选取2021年9月至2022年9月新乡医学院第一附属医院收治的92例下焦湿热型慢性前列腺炎患者作为研究对象,按随机数表法分为观察组和对照组各46例,对照组患者给予西医常规(口服左氧氟沙星及盐酸坦索罗辛缓释胶囊)治疗,观察组患者采取西医常规治疗并结合四妙散加减及针刺治疗,两组患者均治疗1个月。治疗后,比较两组患者的疗效,以及治疗前后的中医证候积分、慢性前列腺炎症状评分(NIHCPSI)、血清炎症因子[白介素-1(IL-1)及白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平和前列腺体积,同时比较两组患者治疗期间的不良反应发生情况。结果观察组患者的治疗总有效率为95.65%,明显高于对照组的82.61%,差异有统计学意义(P<0.05);治疗前,两组患者的中医证候积分、NIHCPSI评分、血清炎症因子水平和前列腺体积比较差异均无统计学意义(P>0.05),治疗后,观察组患者的各项中医证候积分明显低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者的排尿异常、尿道疼痛、睡眠质量评分分别为(2.22±0.49)分、(4.03±1.00)分、(3.01±0.50)分,明显低于对照组的(3.16±0.49)分、(5.74±1.02)分、(3.95±0.47)分,差异均有统计学意义(P<0.05);治疗后,观察组患者的IL-1、IL-6、TNF-α水平分别为(12.38±2.03)ng/L、(34.29±5.21)ng/L、(5.12±0.85)μg/L,明显低于对照组的(16.23±2.16)ng/L、(44.26±4.76)ng/L、(7.83±0.76)μg/L,差异均有统计学意义(P<0.05);治疗后,观察组患者的前列腺体积为(11.05±0.94)mL,明显小于对照组的(12.65±1.02)mL,差异有统计学意义(P<0.05);治疗期间,观察组和对照组患者的总不良反应率分别为4.35%、6.52%,差异无统计学意义(P>0.05)。结论四妙散加减结合针刺治疗下焦湿热型慢性前列腺炎的临床效果甚较好,且安全性较高。Objective To observe the effect of modified Simiao Powder combined with acupuncture in the treatment of chronic prostatitis of lowerjiao dampheat syndrome.Methods Ninetytwo patients with chronic prostatitis of lowerJiao dampheat syndrome admitted to the First Affiliated Hospital of Xinxiang Medical College from September 2021 to September 2022 were selected and divided into the observation group and the control group according to random number table method,with 46 cases in each group.The control group was given conventional Western medicine treatment(oral levofloxacin and Tamsulosin hydrochloride sustainedrelease capsules),and the observation group received conventional Western medicine treatment combined with modified Simiao Powder and acupuncture,both for 1 month.After treatment,the efficacy of the two groups were compared,as well as the TCM syndrome score,chronic prostatic inflammation symptoms score(NIHCPSI),serum inflammatory factors[interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels,and prostate volume before and after treatment.At the same time,the occurrence of adverse reactions during treatment was compared between the two groups.Results The total efficacy rate was 95.65%in observation group,which was significantly higher than 82.61%in the control group(P<0.05).Before treatment,TCM syndrome scores,NIHCPSI scores,serum inflammatory factor levels,and prostatic volume showed no statistically significant difference between the two groups(P>0.05);after treatment,the TCM syndrome scores of the observation group were significantly lower than those of the control group(P<0.05).After treatment,the scores of abnormal urination,urethral pain,sleep quality were(2.22±0.49)points,(4.03±1.00)points,(3.01±0.50)points in the observation group,significantly lower than(3.16±0.49)points,(5.74±1.02)points,(3.95±0.47)points in the control group(P<0.05);the IL-1,IL-6,TNF-αlevels were(12.38±2.03)ng/L,(34.29±5.21)ng/L,and(5.12±0.85)μg/L in the observation group,respectively,significantly l

关 键 词：下焦湿热型 慢性前列腺炎 四妙散加减 针刺 中医证候积分 前列腺体积 

分 类 号：R697.33[医药卫生—泌尿科学]