远隔缺血后适应在心肌梗死中的研究进展  

Remote Ischemic Postconditioning on Rehabilitation of Myocardial Infarction

作　　者：关敏 罗超凡 陈集雅 李阳[1] GUAN Min;LUO Chaofan;CHEN Jiya;LI Yang(Department of Cardiology,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第四医院心内科,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2023年第10期869-873,共5页Advances in Cardiovascular Diseases

摘　　要：再灌注是急性心肌梗死的有效治疗方法,能降低死亡率,改善患者长期预后,然而再灌注治疗也会导致心肌细胞损伤或坏死。远隔缺血后适应是改善心肌缺血再灌注损伤的有效措施,能促进顿抑心肌恢复,对于心肌梗死患者心脏康复具有重要意义。相关机制主要集中在抑制氧化应激、抗凋亡、减轻炎症反应及增加自噬,多种信号分子参与其中。Reperfusion is an effective method for the treatment of acute myocardial infarction,which is of great significance for reducing mortality and improving long-term outcomes.However,reperfusion therapy can also increase damage or necrosis of cardiomyocytes.Remote ischemic postconditioning is an effective measure to improve myocardial ischemia reperfusion injury,and can promote the recovery of stunned myocardium,which is of great significance for cardiac rehabilitation of patients with myocardial infarction.The relevant mechanisms mainly focus on inhibiting oxidative stress,anti-apoptosis,reducing inflammation and increasing autophagy,in which a variety of signaling molecules are involved.

关 键 词：远隔缺血后适应 心肌梗死 缺血再灌注损伤 心肌顿抑 

分 类 号：R542.22[医药卫生—心血管疾病]