神经免疫心血管界面在动脉粥样硬化中的研究进展  

Neuroimmune Cardiovascular Interfaces in Atherosclerosis

作　　者：陈艳华 孙慧 CHEN Yanhua;SUN Hui(Shandong First Medical University,Jinan 250000,Shandong,China;Department of Cardiovascular Medicine,Central Hospital Affiliated to Shandong First Medical University,Jinan 250000,Shandong,China)

机构地区：[1]山东第一医科大学,山东济南250000 [2]山东第一医科大学附属中心医院心血管科,山东济南250000

出　　处：《心血管病学进展》2023年第10期911-915,共5页Advances in Cardiovascular Diseases

基　　金：山东省医药卫生科技发展计划项目(202003011255)。

摘　　要：动脉粥样硬化是心血管疾病的主要驱动因素。动脉粥样硬化的标志是动脉内膜层的粥样斑块。斑块可能损害重要器官的血液供应,导致心血管疾病、脑卒中及其他危及生命的事件发生。动脉粥样硬化中神经支配、白细胞、血管外膜三者相互作用形成广泛的神经免疫心血管界面。另外,急性应激和昼夜节律也是动脉粥样硬化的一部分驱动因素,遗传学技术提供了神经元信号以特定类型和区域的方式调节神经元的能力。现介绍动脉粥样硬化发展的新机制,强调神经免疫学方法作为预防和治疗血管炎症和斑块形成的工具。Atherosclerosis is the major driver of cardiovascular disease.The hallmark of atherosclerosis is the atheromatous plaque in the inner intimal layer of arteries.Plaques may impair blood supply to vital organs leading to heart attacks and strokes and other life-threatening events.The tripartite interaction among innervation leukocytes and the adventitia in atherosclerosis forms the extensive neuroimmune cardiovascular interfaces.Additionally acute stress and circadian rhythms are also part of the drivers of atherosclerosis and genetic techniques have provided the ability of neuronal signals to modulate neurons in a specific type and regional manner.This article introduces novel mechanisms of atherosclerosis development and emphasizes neuroimmunological approaches as tools to prevent and treat vascular inflammation and plaque formation.

关 键 词：神经免疫心血管界面 动脉粥样硬化 急性应激 昼夜节律 遗传学技术 

分 类 号：R543.5[医药卫生—心血管疾病]