2-乙酰基戊二酸二甲酯的合成工艺研究  

Study on the synthesis of dimethyl 2-acetylglutarate

作　　者：徐婷 卢福军 周长海 王瑞菲 刘友彬 岳涛 XU Ting;LU Fu-jun;ZHOU Chang-hai;WANG Rui-fei;LIU You-bin;YUE Tao(Organic Reaction in Aqueous Engineering Research Center of Shandong Province,Jinan 250014,China;Shandong Chemical Technology Academy of Qingdao University of Science&Technology,Jinan 250014,China)

机构地区：[1]山东省水相有机合成及高效清洁分离工程技术研究中心,山东济南250014 [2]青岛科技大学山东化工研究院,山东济南250014

出　　处：《应用化工》2021年第S02期54-57,共4页Applied Chemical Industry

基　　金：山东省“泰山学者”建设工程基金项目(08190201)。

摘　　要：以甲醇钠为催化剂,乙酰乙酸甲酯和丙烯酸甲酯为原料,经Michael加成反应催化合成2-乙酰基戊二酸二甲酯,该路线考察了催化剂、加料方式、物料摩尔比、反应温度、反应时间等对合成2-乙酰基戊二酸二甲酯的影响。结果表明,以甲醇钠为催化剂,甲醇为溶剂,将丙烯酸甲酯和甲醇钠溶液同时滴加至乙酰乙酸甲酯溶液中,反应温度为25℃,反应时间为6 h,乙酰乙酸甲酯、丙烯酸甲酯、甲醇钠摩尔比为1∶1∶0.05。本工艺2-乙酰基戊二酸二甲酯收率为90.63%。Using sodium methoxide as a catalyst,methyl acetoacetate and methyl acrylate as raw materials,dimethyl 2-acetylglutarate was catalyzed by Michael addition reaction.This route investigated the catalyst,feeding method,material molar ratio,and reaction temperature.Reaction time and other effects on the synthesis of dimethyl 2-acetylglutarate.The results showed that using sodium methoxide as a catalyst and methanol as a solvent,the methyl acrylate and sodium methoxide solutions were added dropwise to the methyl acetoacetate solution at the same time.The reaction temperature was 25 C,and the reaction time was 6 h.The molar ratio of ester to sodium methoxide is 1:1:0.05.The yield of dimethyl 2-acetylglutarate in this process is 90.63%.

关 键 词：乙酰乙酸甲酯 2-乙酰基戊二酸二甲酯 MICHAEL加成 甲醇钠 

分 类 号：TQ202[化学工程—有机化工]