杀菌剂氟吡菌酰胺的合成新工艺研究  

Study on a new synthesis process of fluopyram

作　　者：王威[1] 黄晓瑛[1] 尚宇 郑晓蕊[1] 刘康云[1] 王列平[1] WANG Wei;HUANG Xiao-ying;SHANG Yu;ZHENG Xiao-rui;LIU Kang-yun;WANG Lie-ping(State Key Laboratory of Fluorine&Nitrogen Chemicals,Xi'an Modern Chemistry Research Institute,Xi'an 710065,China;Shaanxi Environmental Monitoring Center,Xi'an 710054,China)

机构地区：[1]西安近代化学研究所氟氮化工资源高效开发与利用国家重点实验室,陕西西安710065 [2]陕西省环境监测中心站,陕西西安710054

出　　处：《应用化工》2021年第S02期109-112,共4页Applied Chemical Industry

基　　金：西安市科技计划项目(2020KJRC0145)。

摘　　要：以2,3-二氯-5-三氟甲基吡啶为原料,经烷基化和脱羧的间歇式连续化反应、氢化还原、水相参与的酰胺化制得氟吡菌酰胺。该合成新工艺路线简单合理,利用烷基化和脱羧反应的连续化操作,降低了三废排放,节约了成本;利用水相参与的酰胺化反应,缩短了反应时间,产品总收率达到47.9%,含量97%,具有一定的应用前景。Fluopyram is synthesized from 2,3-dichloro-5-trifluoromethylpyridine by intermittent continuous operation of alkylation and decarboxylation reaction,hydrogenation reduction and amidation with the participation of aqueous phase.The synthesis method utilizes the continuous operation of alkylation and decarboxylation reaction,which reduces the emission of three wastes and saves the cost,and uses the aqueous phase to participate in the amidation reaction,which shortens the reaction time.The total yield of the product reaches 47.9%,and the product purity reaches 97%.The synthesis method is reasonable,which has a prospect of application.

关 键 词：氟吡菌酰胺 合成 工艺优化 水相反应 

分 类 号：TQ217[化学工程—有机化工] TQ457.26[理学—有机化学] O622.6[理学—化学]