新生儿脓毒症相关性凝血病的监测和治疗  

Monitoring and treatment of neonatal sepsis-induced coagulopathy

作　　者：魏徐 张鸽 伍金林 Wei Xu;Zhang Ge;Wu Jinin(Department of Pediatrics,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China;Department of Laboratory Medicine,West China Second University Hospital,Sichuan University,Chengdu 61004l,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041 [2]四川大学华西第二医院医学检验科,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2023年第4期379-386,共8页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技厅应用基础项目(2021YJ0211);四川大学横向课题(21H0865)。

摘　　要：脓毒症相关性凝血病(SIC)是新生儿常见疾病,亦是导致新生儿死亡的重要原因。目前认为,SIC新生儿中,机体炎症和凝血功能紊乱具有密切关系,但是二者相互作用机制则迄今尚未阐明,对于预防脓毒症新生儿发生SIC的治疗方案,目前亦尚无统一标准。笔者拟就新生儿SIC的发病机制、血清监测指标和治疗的最新研究进展进行阐述,旨在为新生儿SIC的进一步临床与基础研究提供参考依据,改善SIC新生儿预后。Sepsis-induced coagulopathy (SIC) is a common disease in newborns and an important cause of neonatal death. At present, it is believed that there is a close relationship between inflammation and coagulation dysfunction in SIC newborns, but the mechanism of their interaction is still unclear, and it is lack of uniform standard treatment plan to prevent SIC in newborns with sepsis. The author intends to elaborate on the latest research progress in pathogenesis, serum monitoring indicators, and treatment of neonatal SIC, with the aim of providing reference for further clinical and basic research on SIC and improving the prognosis of newborns with SIC.

关 键 词：新生儿脓毒症 纤维蛋白纤维蛋白原降解物 凝血酶 全身炎症反应综合征 纤维蛋白溶解 脓毒症相关性凝血病 生物标志物 婴儿 新生 疾病 

分 类 号：R722.1[医药卫生—儿科]