小柴胡汤化学成分、药理作用研究进展及质量标志物(Q-Marker)预测  

Research progress on chemical constituents and pharmacological effects of Xiaochaihu Decoction and predictive of its quality marker(Q-Marker)

作　　者：劳梓滢 蒋智锐 张靖怡 李彪平 杨加顺 唐玲 LAO Zi-ying;JIANG Zhi-rui;ZHANG Jing-yi;LI Biao-ping;YANG Jia-shun;TANG Ling(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics/Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology,Guangzhou 510515,China;The Seventh Affiliated Hospital of Southern Medical University,Foshan 528244,China)

机构地区：[1]南方医科大学中医药学院,广东广州510515 [2]广东省中药制剂重点实验室/广东省中药制剂技术工程实验室,广东广州510515 [3]南方医科大学第七附属医院,广东佛山528244

出　　处：《中草药》2023年第19期6520-6530,共11页Chinese Traditional and Herbal Drugs

摘　　要：经典名方小柴胡汤具有和解少阳、扶正祛邪之效,具有解热、抗炎、保肝、抗肿瘤、抗病毒、免疫调节等药理作用,目前临床多用于治疗感冒发热、抗菌消炎、保护肝脏等。通过对小柴胡汤的化学成分、药理作用及临床应用进行综述,参照中药质量标志物(quality marker,Q-Marker)的“五原则”对小柴胡汤进行预测分析,结果显示柴胡皂苷A、柴胡皂苷B2、柴胡皂苷D、人参皂苷Rb1、人参皂苷Rg1、黄芩苷、黄芩素、精氨酸、鸟苷、6-姜烯酚、6-姜酚、甘草苷、甘草酸、甘草次酸、白桦脂酸可作为小柴胡汤的Q-Markers,为补充小柴胡汤质量评价及控制体系、完善制剂全过程质量溯源体系提供科学的参考依据。The classic famous formula Xiaochaihu Decoction has the effects of harmonizing lesser yang,and reinforcing healthy qi and eliminating pathogen.It also has pharmacological effects like antipyretic,anti-inflammatory,hepatoprotective,anti-tumor,antiviral,and immunomodulatory,etc.At present,it is mostly used in clinical treatment of cold and fever,antibacterial and antiinflammatory,and liver protection.The chemical composition,pharmacological effects and clinical applications of Xiaochaihu Decoction were reviewed,and the predictive analysis of Xiaochaihu Decoction was carried out with reference to the“five principles”of quality marker(Q-marker)of traditional Chinese medicine.The results indicated that baicalin,arginine,guanosine,6-shogaol,6-gingerol,glycyrrhizin,glycyrrhizic acid,glycyrrhizinic acid,and betulinic acid could be used as quality markers of Xiaochaihu Decoction,providing a scientific reference basis for supplementing the quality evaluation and control system of Xiaochaihu Decoction and improving the whole process quality traceability system of the preparation.

关 键 词：小柴胡汤 质量标志物 药理作用 临床应用 柴胡皂苷A 柴胡皂苷D 人参皂苷RB1 人参皂苷Rg1 黄芩苷 黄芩素 6-姜烯酚 6-姜酚 

分 类 号：R285[医药卫生—中药学]