数字光处理技术成形β-磷酸三钙生物陶瓷及其生物学评价  

Fabrication ofβ-tricalcium Phosphate Bioceramics by Digital Light Processing Technique and Its Biological Evaluation

作　　者：刘玮玮 李攀 李浩 赵一风 刘荣臻 李家良[3] LIU Wei-wei;LI Pan;LI Hao;ZHAO Yi-feng;LIU Rong-zhen;LI Jia-liang(Xi’an Additive Manufacturing National Institute Co.,Ltd.,Xi’an 710117,China;School of Materials Science and Engineering,Xi’an Jiaotong University,Xi’an 710049,China;Xi’an Honghui Hospital,Xi’an 710054,China)

机构地区：[1]西安增材制造国家研究院有限公司,西安710117 [2]西安交通大学材料科学与工程学院,西安710049 [3]西安红会医院,西安710054

出　　处：《精密成形工程》2023年第11期69-75,共7页Journal of Netshape Forming Engineering

基　　金：陕西省重点研发计划重点产业创新链项目(2017KTZD6-01);陕西省科技统筹创新工程计划(2016KTZDGY4-06)。

摘　　要：目的研究数字光处理技术(Digital Light Processing,DLP)打印β-磷酸三钙(Beta-Tricalcium Phosphaye,β-TCP)生物陶瓷的成形性能与生物学性能。方法通过表面活性剂硬脂酸改性β-TCP粉体,将改性后的β-TCP粉体与丙烯酸类及甲基丙烯酸类树脂均匀混合成3D打印浆料,进行3D打印性能研究。采用X射线衍射仪(X-RayDiffraction,XRD)、接触角测量仪、数字式黏度计表征β-TCP粉体、浆料及3D打印支架性能,并进行体外细胞试验研究β-TCP多孔支架的生物学性能。结果粉体XRD结果显示,硬脂酸改性β-TCP粉体并未影响原始粉体的物相组成;而表面活性剂硬脂酸降低了树脂与粉体表面的接触角,提高了粉体与树脂的亲和性。3D打印β-TCP浆料的固含量为48%(体积分数),在常温下,黏度仅为2.91Pa·s。支架XRD结果显示,3D打印β-TCP多孔支架的主要物质仍为β-TCP,仅有部分转化为α-TCP。体外细胞试验表明,3D打印β-TCP支架表面可黏附大量细胞,培养7d后,细胞延伸至支架孔隙内,同时其溶血性结果较钛合金(Ti6Al4V)及聚醚醚酮(PEEK)的优异。结论3D打印β-TCP多孔支架可作为骨替代植入物,为治疗临床骨缺损疾病提供新途径。The work aims to study the formability and biological properties ofβ-Tricalcium Phosphate(β-TCP)bioceramics printed by digital light processing(DLP)technique.β-TCP powder modified by surfactant stearic acid was evenly mixed with acrylic resins and methacrylic resin to form 3D printed slurry,and then the 3D printed process was verified.An X-ray diffractometer(XRD),a contact Angle measuring instrument,and a digital viscometer were used to characterize the properties ofβ-TCP powder,slurry and 3D printed scaffolds.The biological properties ofβ-TCP porous scaffolds were studied by cell and animal experiments.The powder XRD results showed that the modification ofβ-TCP powder did not affect the phase composition of the powder.The surfactant stearic acid reduced the contact angle between the resin and the powder surface,and improved the af-finity between the powder and the resin.The solid content of 3D printedβ-TCP slurry was 48vol.%and the viscosity was only 2.91 Pa·s at room temperature.The scaffold XRD results showed that the main substance of sintered scaffold wasβ-TCP,and part of it was transformed intoα-TCP.In vitro cell experiments showed that the surface of 3D printedβ-TCP scaffolds could adhere to a large number of cells.After 7 days of culture,the cells extended into the pores of the scaffold.And the hemolytic re-sults were better than those of Ti6Al4V and PEEK.3D printedβ-TCP porous scaffolds can be used as bone replacement implants,providing a new way to treat clinical bone defect diseases.

关 键 词：数字光处理 3D打印 Β-磷酸三钙 生物陶瓷 生物学性能 

分 类 号：TH145.9[一般工业技术—材料科学与工程] TB321[机械工程—机械制造及自动化]