不同促渗剂对芍药苷凝胶体外透皮吸收的影响  

Effect of different penetration enhancers on percutaneous absorption of paeoniflorin in vitro

作　　者：胡远康 钟雨虹 刘志东[1,2] 祁东利[1,2] HU Yuankang;ZHONG Yuhong;LIU Zhidong;QI Dongli(State Key Laboratory of Component-Based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Ministry of Education,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学组分中药国家重点实验室,天津301617 [2]天津中医药大学现代中药发现与制剂技术教育部工程中心,天津301617

出　　处：《天津中医药大学学报》2023年第5期630-635,共6页Journal of Tianjin University of Traditional Chinese Medicine

摘　　要：[目的]研究芍药苷(PF)的理化性质及考察薄荷油、桉叶油、油酸、氮酮4种促渗剂对PF凝胶中PF体外透皮吸收的影响,筛选出最佳的促渗剂。[方法]采用摇瓶法测定PF的表观溶解度及油水分配系数;采用改良Franz扩散池,以大鼠离体皮肤为模型,通过高效液相色谱(HPLC)法测定药物浓度,拟合PF透皮吸收的累积透过量和透过速率。[结果] 7%薄荷油、5%薄荷油、4%桉叶油及3%油酸均可以不同程度地促进PF凝胶中PF透皮吸收,其促渗效果顺序为7%薄荷油>5%薄荷油>4%桉叶油>3%油酸。[结论] 7%薄荷油为PF凝胶的最佳促渗剂。[Objective]To study the physical and chemical properties of paeoniflorin(PF)and the effects of peppermint oil,eucalyptus oil,oleic acid,azone and four penetration enhancers on the percutaneous absorption of PF in PF gel in vitro.[Methods]The apparent solubility and oil-water partition coefficient of PF were determined by shake-flask method,and the concentration of PE in rat skin was determined by HPLC,accumulation of PF and its permeation rate through rat skin.[Results]The 7%peppermint oil,5%peppermint oil,4%eucalyptus oil and 3%oleic acid could improve the transdermal absorption of PF gel,the order of enhancing permeability was 7%peppermint oil>5%peppermint oil>4%eucalyptus oil>3%oleic acid.[Conclusion]The 7%peppermint oil was the best penetration enhancer for PF gel.

关 键 词：芍药苷 透皮吸收 促渗剂 

分 类 号：R283[医药卫生—中药学]