毛囊间充质干细胞的基础研究及临床应用  

Basic research and clinical application of hair follicle-derived mesenchymal stem cells

作　　者：袁久莉[1] 刘丹 李林藜[2] 刘晋宇[3] Yuan Jiuli;Liu Dan;Li Linli;LiuJinyu(Jing Yue Branch Preparatory Group,the First Hospital of Jilin University,Changchun 130021,China;College of Public Health of Jilin University,Changchun 130021,China;Department of Gynecology and Obstetrics,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院净月分院筹备组,长春130021 [2]吉林大学第一医院妇产科,长春130021 [3]吉林大学公共卫生学院,长春130021

出　　处：《中华细胞与干细胞杂志（电子版）》2023年第3期189-192,共4页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金项目(82073581);吉林省科技发展计划项目(20190304044YY、20200801022GH)。

摘　　要：以干细胞为核心的再生医学成为当今医学研究的热点。研究发现人毛囊中含有多种干细胞成份,包括但不限于角朊干细胞、黑色素干细胞、间充质干细胞(MSCs)和神经脊干细胞。这些干细胞在时空上相互作用,共同维持毛囊的稳态。其中毛囊间充质干细胞(HF-MSCs)不仅参与毛发的发生、生长和周期循环,而且还可以作为一种重要的自体干细胞来源,用于组织修复、器官重建和基因治疗。本文就HF-MSCs基础医学研究领域取得的进展以及在临床多种疾病治疗中的应用作一简要综述。Stem cell-based regenerative medicine become the hotspot in current medical research.Accumulating studies showed that human hair follicles contain various stem cell components,including but not limited to keratinocyte stem cells,melanocyte stem cells,mesenchymal stem cells(MSCs)and neural crest cells.These hair follicle-derived stem cells interact in a coordinated temporal and spacial manner to maintain hair follicle homeostasis.Hair follicle-derived mesenchymal stem cells(HF-MSCs)participate in hair generation,hair growth and hair follicle cycle and can be used as an essential autologous stem cell source to participate in tissue repair,organ reconstruction and gene therapy.This review focuses on advances of HF-MSCs in the basic medical research and their application in the treatment of various clinical diseases.

关 键 词：毛囊 间充质干细胞 基础研究 临床应用 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]