2-甲基-4-氯苯酚的绿色合成工艺  

Green synthesis process of 4-chloro-2-methylphenol

作　　者：付永丰 高爱红 高修正 夏雪强 刘友彬 岳涛 FU Yongfeng;GAO Aihong;GAO Xiuzheng;XIA Xueqiang;LIU Youbin;YUE Tao(Organic Reaction in Aqueous Engineering Research Center of Shandong Province,Chemical Technology Academy of Shandong Province,Qingdao University of Science&Technology,Jinan 250014,China)

机构地区：[1]青岛科技大学山东化工研究院山东省水相有机合成及高效清洁分离工程技术研究中心,济南250014

出　　处：《农药》2023年第10期716-719,共4页Agrochemicals

基　　金：泰山学者建设工程项目基金(ts20130918)。

摘　　要：[目的]开发一种绿色、高选择性的2-甲基-4-氯苯酚生产方法。[方法]以2-甲基苯酚为原料、盐酸为氯化试剂及溶剂、氯化铜为催化剂,反应体系通氧,实现氯化铜原位氧化氯化制备2-甲基-4-氯苯酚。[结果]2-甲基-4-氯苯酚的收率为98.5%,选择性97.4%。[结论]本工艺消耗盐酸,解决了现有工艺大量生成副产物盐酸的问题,符合绿色化工宗旨。[Aims]This study aims to develop a green and highly selective method for producing 4-chloro-2-methylphenol[Methods]4-Chloro-2-methylphenol was prepared using 2-methylphenol as the raw material hydrochloric acid as the chlorination reagent and solvent and copper chloride as the catalyst Copper chloride underwent in-situ oxidative chlorination by introducing oxygen into the reaction system.[Results]The yield of 4-chloro-2-methylphenol was 98.5%and the selectivity was 97.4%.[Conclusions]This process consumes hydrochloric acid,solving the problem of large amounts of hydrochloric acidby-produced by existing methods.This aligns with goals of green chemical industry by reducing waste.

关 键 词：2-甲基苯酚 2-甲基-4-氯苯酚 氯化铜 氯代反应 

分 类 号：TQ243.3[化学工程—有机化工] TQ457.2