孕期血浆游离DNA相关指标对不良妊娠结局预测价值的研究进展  

Research progress on predictive value of plasma cell-free DNA related indicators in pregnancy for adversepregnancy outcome

作　　者：梅凤琦 刘彦慧 MEI Feng-qi;LIU Yan-hui(Shunde Women and Children’s Hospital of Guangdong Medical University,Foshan 528300;Guangdong Medical University,Zhanjiang 523808;Shenzhen Luohu People’s Hospital,Shenzhen 518000)

机构地区：[1]广东医科大学顺德妇女儿童医院,佛山528300 [2]广东医科大学,湛江523808 [3]深圳市罗湖区人民医院,深圳518000

出　　处：《生殖医学杂志》2023年第11期1766-1770,共5页Journal of Reproductive Medicine

摘　　要：不良妊娠结局会影响胎儿的生长发育,并威胁母婴生命安全。因此,不良妊娠结局的早筛查、早发现、早预防对母婴健康尤为重要。孕期血浆游离DNA(cfDNA)主要来自母体髓系/淋巴系细胞和胎盘滋养细胞,其中cfDNA浓度、游离胎儿DNA分数、线粒体DNA、核小体启动子等cfDNA相关指标对不良妊娠结局的预测价值各不相同,本文就近年来各cfDNA相关指标预测常见不良妊娠结局的研究进展进行综述。Adverse pregnancy outcomes can affect the growth and development of the fetus and threaten the safety of mother and fetus.Therefore,early screening,early detection and early prevention are particularly important for the health of mothers and infants.During pregnancy,plasma cell-free DNA(cfDNA)mainly come from maternal myeloid/lymphoid cells and placental trophoblasts.Among them,the cfDNA concentration,cell-free fetal DNA fraction,mitochondrial DNA,nucleosome promoter and other cfDNA related indicators have different predictive values for adverse pregnancy outcomes.This paper reviews the research progress of various cfDNA related indicators in predicting common adverse pregnancy outcomes in recent years.

关 键 词：血浆游离DNA 游离胎儿DNA分数 线粒体DNA 核小体启动子 不良妊娠结局 

分 类 号：R715.5[医药卫生—妇产科学]